氨基糖苷类抗生素耳毒性影响因素研究进展  

Research progress on influencing factors of aminoglycoside antibiotic ototoxicity

作　　者：李聪 李玲[1,2] 刘亭彦[3] 陈良[2] LI Cong;LI Ling;LIU Tingyan;CHEN Liang(The 2nd Medical College of Binzhou Medical University,Yantai 264100,Shandong,China;Department of Otorhinolaryngology&Head and Neck Surgery,Yantai Yuhuangding Hospital,Qingdao University/Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases,Yantai 264099,Shandong,China;Department of Otorhinolaryngology&Head and Neck Surgery,YanTai Affiliated Hospital of Binzhou Medical University,Yantai 264199,Shandong,China)

机构地区：[1]滨州医学院第二临床医学院,山东烟台264100 [2]青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科/山东省耳鼻喉疾病临床医学研究中心,山东烟台264099 [3]滨州医学院烟台附属医院耳鼻咽喉头颈外科,山东烟台264199

出　　处：《山东大学耳鼻喉眼学报》2023年第2期128-134,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：烟台市科技计划项目(2020MSGY078)。

摘　　要：氨基糖苷类抗生素是一类广泛使用的治疗严重细菌感染的关键药物,耳毒性为药物的严重并发症,其主要病因是药物触发的内耳感觉毛细胞死亡。介导感觉毛细胞死亡的分子事件一直以来被广泛研究。近年来关于增加药物毒性的外在因素及导致个体敏感性增加的遗传因素不断被揭示,为氨基糖苷类抗生素耳毒性的预防及个体化治疗提供可能。现对氨基糖苷类抗生素内耳损害机制、影响药物耳毒性的多个因素及预防氨基糖苷类药物耳毒性的潜在干预策略的最新研究进展进行综述。Aminoglycoside antibiotics are potent and widely used primarily in the treatment of serious bacterial infections.A serious complication from using these antibiotics is ototoxicity.The main cause of ototoxicity is drug-triggered sensory hair cell damage in the inner ear.Molecular events that engender aminoglycoside-induced sensory hair cell death have been extensively studied.Recent reports have revealed the external factors that increase drug toxicity and the genetic factors that lead to increased sensitivity in individuals,which may provide prospective approach for individualized treatment and prevention of ototoxicity.In this review,we discuss the ototoxicity mechanism of aminoglycoside antibiotics,factors affecting drug ototoxicity,and potential intervention strategies to prevent ototoxicity.

关 键 词：氨基糖苷类抗生素 耳毒性 基因易感性 炎症 糖皮质激素 

分 类 号：R764[医药卫生—耳鼻咽喉科]