肝移植供体来源研究进展  

Advances in donor sources for liver transplantation

作　　者：陈咏怡 徐亚奇 段军[2] Chen Yongyi;Xu Yaqi;Duan Jun(Graduate School of Peking Union Medical College,Beijing 100730,China;Department of Intensive Care Unit,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京协和医学院研究生院,北京100730 [2]中日友好医院重症医学科,北京100029

出　　处：《中国医师杂志》2023年第4期638-640,F0003,共4页Journal of Chinese Physician

基　　金：中日友好医院高水平医院临床业务费专项临床研究项目(2022-NHLHCRF-LX-03)。

摘　　要：肝移植是终末期肝病的标准治疗手段,目前供肝来源短缺很大程度上限制了肝移植的发展。通过开展活体肝移植,解决了部分供肝来源问题。然而尸体肝移植仍占供肝来源的绝大部分。近年来,包括手术方式和机械灌注等技术方法的创新,使得临床实现了"一肝多用"并增加了移植物生存率。"边缘供体"移植是一种可靠的扩大供体池的方法,这依赖相关人员对于供肝的评估和维护。本文将阐述肝移植的供体来源及扩大供体池的途径。Liver transplantation is a standard therapy for end-stage liver disease.The shortage of donor has greatly tethered the development of liver transplantation.With the use of living donors,we actually solved some problems.Nevertheless,cadaveric liver transplantation still accounts for the vast majority of liver donors.In recent years,technological innovations,including surgical methods and mechanical perfusion,have enabled the clinical realization of"multi-purpose liver"and increased graft survival rate."Marginal donor"transplantation is a reliable way to expand the donor pool,which depends on the evaluation and maintenance of the donor liver.This review will describe the source of donors for liver transplantation and the way to expand donor pool.

关 键 词：肝移植 供体 

分 类 号：R657.3[医药卫生—外科学]