Implantable optical fiber microelectrode with anti-biofouling ability for in vivo photoelectrochemical analysis  

作　　者：Lixia Tao Yao Kong Yunhui Xiang Yu Cao Xiaoxue Ye Zhihong Liu 

机构地区：[1]College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China [2]Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering,Wuhan 430072,China

出　　处：《Chinese Chemical Letters》2023年第3期259-263,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21625503 and 21906047);Natural Science Fund for Creative Research Groups of Hubei Province of China(No.2020CFA035)。

摘　　要：In-situ monitoring of neurochemicals is of vital importance for the understanding of brain functions.Microelectrode-based photoelectrochemical(PEC) sensing has emerged as a promising tool for in vivo analysis since it inherits the merits of both optical and electrochemical methods. However, the in-situ excitation of photoactive materials on the photoelectrode in living body is still a challenge because of limited tissue penetration depth of light. To circumvent this problem, we herein developed an implantable optical fiber(OF)-based microelectrode for in vivo PEC analysis. The working electrode was constructed by coating Au film as conducting layer and CdS@ZnO as photoactive material on a micron-sized OF,which was free of the limitation of light penetration in biological tissues. Further decoration of an antibiofouling layer on the surface made the sensor robust in biosamples. It was successfully applied for monitoring Cu^(2+) level in three different brain regions in the rat model of cerebral ischemia/reperfusion.

关 键 词：Optical fiber Implantable microelectrode Photoelectrochemical sensing In vivo analysis Neurochemicals 

分 类 号：R313[医药卫生—基础医学] O657.1[理学—分析化学]