2D graphene oxide-L-arginine-soybean lecithin nanogenerator for synergistic photothermal and NO gas therapy  

作　　者：Haina Tian Jinyan Lin Fukai Zhu Jiaqi Li Suhua Jiang Liya Xie Yang Li Peiyuan Wang Zhenqing Hou Jinxiao Mi 

机构地区：[1]Department of Biomaterials,College of Materials,Research Center of Biomedical Engineering of Xiamen&Key Laboratory of Biomedical Engineering of Fujian Province,Xiamen University,Xiamen 361005,China [2]Key Laboratory of Design and Assembly of Functional Nanostructures,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China [3]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province,Mengchao Hepatobiliary Hospital of Fujian Medical University,Fuzhou 350025,China [4]Collaborative Innovation Center of Mushroom Health Industry,Minnan Normal University,Zhangzhou 363000,China [5]School of Rare earths,University of Science and Technology of Chin,Hefei 230026,China [6]The First Affiliated Hospital of Xiamen University,Xiamen 361003,China [7]Department of Materials Science and Engineering,Fujian Provincial Key Laboratory of Advanced Materials(Xiamen University),College of Materials,Xiamen University,Xiamen 361005,China

出　　处：《Chinese Chemical Letters》2023年第3期402-408,共7页中国化学快报（英文版）

基　　金：funding from the National Natural Science Foundation of China(Nos.61905248,62005284 and 82001950);Natural Science Foundation of Fujian Province of China(No.2019J01572);China Postdoctoral Science Foundation(No.2020M671928);Research Start-up Funding of the Mengchao Hepatobiliary Hospital of Fujian Medical University(No.QDZJ2019-003);Youth Innovation Foundation of Xiamen City(No.3502Z20206084)。

摘　　要：Nitric oxide(NO) gas therapy has been regarded as a promising strategy for cancer treatment. However,its therapeutic efficiency is still unsatisfying due to the limitations of monotherapy. Previous preclinical and clinical studies have shown that combination therapy could significantly enhance therapeutic efficiency. Herein, a graphene oxide(GO)-L-arginine(L-Arg, a natural NO donor) hybrid nanogenerator is developed followed by surface functionalization of soybean lecithin(SL) for synergistic enhancement of cancer treatment through photothermal and gas therapy. The resultant GO-Arg-SL nanogenerator not only exhibited good biocompatibility and excellent endocytosis ability, but also exhibited excellent photothermal conversion capability and high sensitivity to release NO within tumor microenvironment via inducible NO synthase(i NOS) catalyzation. Moreover, the produced hyperthermia and intracellular NO could synergistically kill cancer cells both in vitro and in vivo. More importantly, this nanogenerator can efficiently eliminate tumor while inhibiting the tumor recurrence because of the immunogenic cell death(ICD) elicited by NIR laser-triggered hyperthermia and the immune response activation by massive NO generation. We envision that the GO-Arg-SL nanogenerator could provide a potential strategy for synergistic photothermal and gas therapy.

关 键 词：NO gas therapy Photothermal therapy L-ARG Immune activation Reduce recurrence 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]