棕色脂肪组织生物学的研究进展  

Research advances in brown adipose tissue biology

作　　者：王潇 李梁[1] 崔成立[1] 蔡志平[1] 张柏峰 宋巍 王福奇 Wang Xiao;Li Liang;Cui Chengli;Cai Zhiping;Zhang Baifeng;Song Wei;Wang Fuqi(Department of Human Anatomy,School of Basic Medicine,Baotou Medical College,Baotou 014040,China)

机构地区：[1]包头医学院基础医学部人体解剖学教研室,包头014040

出　　处：《解剖学杂志》2023年第1期49-52,共4页Chinese Journal of Anatomy

基　　金：内蒙古自治区自然科学研究项目(2019MS08199)。

摘　　要：棕色脂肪组织(BAT)能够激活机体产热以及增加全身能量损耗,为治疗超重、肥胖及相关代谢类疾病提供了新思路。在低温、冷环境暴露和β肾上腺素能受体激动剂等影响下,可以激活棕色脂肪组织产热,并能促使白色脂肪细胞向棕色样细胞分化(白色脂肪组织棕色化),提高这些细胞的产热活性。本文对与BAT和能量消耗相关的新机制,与BAT产热相关的新见解,啮齿类动物和人类之间BAT代谢的不同特征进行综述。Brown adipose tissue(BAT)can activate a body's thermogenic activity and increase systemic energy expenditure.It supplies a new way to fight obesity and associated metabolic to diseases.Cold stimulation andβ-adrenergic receptor agonists can activate BAT to produce heat,boost white adipocytes to differentiate into brown adipocytes(beige adipocytes),and improve the thermogenic activity of these cells.New mechanisms associated with BAT and energy expenditure,new insights related to BAT thermogenesis,and different features of BAT metabolism between rodents and humans are reviewed.

关 键 词：棕色脂肪组织 产热 机制 

分 类 号：R329.1[医药卫生—人体解剖和组织胚胎学]