转化生长因子β1与子痫前期的研究进展  

Research progress of transforming growth factorβ1 and preeclampsia

作　　者：袁明[1] 李建华 Yuan Ming;Li Jianhua(Department of Human Anatomy,School of Basic Medicine,Qinghai University School of Medicine,Xining 810016,China)

机构地区：[1]青海大学医学部基础医学部人体解剖学教研室,西宁810016

出　　处：《解剖学杂志》2023年第1期52-56,共5页Chinese Journal of Anatomy

基　　金：青海省科技厅项目(2019-SF-134)。

摘　　要：子痫前期是复杂的妊娠特异性疾病,严重者会引起HELLP综合征(溶血、肝酶升高和血小板减少),是孕产妇和婴幼儿死亡的主要原因。转化生长因子β1(TGF-β1)是具有多种生物活性的多肽生长因子,已被证明是胚胎发育和调节滋养层细胞活动所需的多功能细胞因子,在母胎免疫稳态、血管形成及血管张力调控中发挥着重要作用。因此,TGF-β1可能成为子痫前期的生物标记物。Preeclampsia is a complex pregnancy-specific disease that can seriously cause HELLP syndrome(hemolysis,elevated liver enzymes,and thrombocytopenia),which is the main cause of maternal and infant mortality.Transforming growth factorβ1(TGF-β1)is a polypeptide growth factor containing a variety of biological activities.It has been proved to be a multifunctional cytokine required for embryonic development and regulation of trophoblast cell activities,and plays an important role in maternal-fetal immune homeostasis,angiogenesis and regulation of vascular tension.Therefore,TGF-β1 may be a biomarker for preeclampsia.

关 键 词：转化生长因子Β1 子痫前期 胎盘 基因多态性 

分 类 号：R714.244[医药卫生—妇产科学]