腺垂体功能减退症123例临床分析  

Clinical analysis of 123 cases of hypopituitarism

作　　者：尹倩倩 潘天荣[1] 钟兴[1] 杜益君[1] YIN Qianqian;PAN Tianrong;ZHONG Xing;DU Yijun(Department of Endocrinology,The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China)

机构地区：[1]安徽医科大学第二附属医院内分泌科,安徽合肥230601

出　　处：《安徽医药》2023年第6期1207-1210,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 提高对腺垂体功能减退症的认识。方法 对安徽医科大学第二附属医院内分泌科2015年8月至2020年9月收治的123例腺垂体功能减退症病人的资料进行回顾性分析。结果 男47例(38.2%),女76例(61.8%),年龄范围16~83岁。颅内占位或术后49例(39.9%),希恩综合征39例(31.7%),空泡蝶鞍综合征15例(12.2%),下丘脑-垂体发育不良9例(7.3%),病因不明11例(8.9%)。以消化道症状就诊47例(38.2%,为首要就诊症状),垂体危象23例(18.7%)。性腺轴受损104例(86.7%,为最主要受损腺体),3个腺体(性腺轴、甲状腺轴、肾上腺轴)均受损61例(55.5%)。低钠血症60例(52.2%),血脂异常87例(75%),低血糖21例(18.8%),贫血47例(40.9%)。结论 腺垂体功能减退症临床表现多样,应提高对该病的认识,避免误诊和漏诊,确诊后及时予以激素替代治疗。Objective To improve the understanding of hypopituitarism.Methods Data from 123 patients with hypopituitarism admitted to the Department of Endocrinology,the Second Affiliated Hospital of Anhui Medical University,from August 2015 to September 2020 were retrospectively analyzed.Results There were 47 cases(38.2%)of males and 76 cases(61.8%)of females,with an age range of 16 to 83 years.There were 49 cases(39.9%)of intracranial or postoperative occupancy,39 cases(31.7%)of Sheehan's syndrome,15 cases(12.2%)of vacuolant saddle syndrome,9 cases(7.3%)of hypothalamus-pituitary dysplasia,and 11 cases(8.9%)of unknown etiology.There were 47 patients(38.2%,the primary presenting symptom)with gastrointestinal symptoms and 23 patients(18.7%)with pituitary crisis.The gonadal axis was damaged in 104 cases(86.7%,the most predominantly damaged gland),and all 3 glands(gonadal axis,thyroid axis,and adrenal axis)were damaged in 61 cases(55.5%).Hyponatremia was observed in 60 cases(52.2%),dyslipidemia in 87 cases(75%),hypoglycemia in 21 cases(18.8%),and anemia in 47 cases(40.9%).Conclusion The clinical manifestations of hypopituitarism are diverse,awareness of the disease should be improved to avoid misdiagnosis and underdiagnosis,and hormone replacement therapy should be given promptly after diagnosis.

关 键 词：腺垂体功能减退症 靶腺轴功能减退 低钠血症 高脂血症 低血糖 贫血 垂体危象 激素替代 

分 类 号：R584.2[医药卫生—内分泌]