小鼠精子形成过程中顶体发生的超微结构变化  

Ultrastructural changes of acrosome biogenesis during spermiogenesis in mouse

作　　者：张姝 杨琳 冯雅琴[1] ZHANG Shu;YANG Lin;FENG Ya-qin(Department of Histology and Embryology,Shanxi Medical University,Taiyuan Shanxi 030001;Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,State Key Laboratory of Molecular Developmental Biology,Beijing 100101,China)

机构地区：[1]山西医科大学组织胚胎学教研室,太原山西030001 [2]中国科学院遗传与发育生物学研究所,分子发育生物学国家重点实验室,北京100101

出　　处：《电子显微学报》2023年第2期192-198,共7页Journal of Chinese Electron Microscopy Society

基　　金：国家自然科学基金资助项目(No.30900777);山西省青年科技研究基金资助项目(No.2010021036-1);山西医科大学博士启动基金(No.03200804)。

摘　　要：顶体是精子头部覆盖在细胞核前面的一个溶酶体相关细胞器,在精子细胞变态过程中逐步形成,精卵结合时发挥重要作用。顶体形态异常是男性不育常见的原因之一。关于顶体形成过程的超微结构变化缺少系统性观察报道。本研究以小鼠睾丸为研究对象,在透射电镜下观察精子细胞顶体形成过程中的形态演变,为深入研究顶体发生的分子机制提供形态学依据。The acrosome is a lysosome-related organelle located over the anterior part of the sperm nucleus.Formation of the acrosome is associated with spermatid differentiation during spermiogenesis.Acrosome plays an important role in the fertilization.Spermatozoa of malformed acrosome is one of the most common reasons for male infertile.Ultrastructural study of acrosome biogenesis remains poorly reported systemically.In this study,morphological characterization of mouse acrosome during acrosomogenesis is observed under the transmission electron microscope,which supplies the morphological basis for further exploration of molecular mechanisms.

关 键 词：顶体发生 超微结构 小鼠 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学] Q954.43[医药卫生—基础医学] S852.1[生物学—动物学] Q336[农业科学—基础兽医学]