miRNAs对动脉粥样硬化作用的研究进展  

Research progress of miRNAs on atherosclerosis

作　　者：陈雅娇 李涛[2] 许泼实[2] CHEN Yajiao;LI Tao;XU Poshi(Henan University of Chinese Medicine,Zhengzhou,Henan,China,450018;Clinical Laboratory,Henan Provincial People’s Hospital,Fuwai Central China Cardiovascular Hospital,Zhengzhou,Henan,China,451464)

机构地区：[1]河南中医药大学,河南郑州450018 [2]河南省人民医院阜外华中心血管病医院检验科,河南郑州451464

出　　处：《分子诊断与治疗杂志》2023年第4期545-548,553,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关计划(222102310456);河南省中青年卫生健康科技创新优秀青年人才培养项目(YXKC2022043)。

摘　　要：动脉粥样硬化(AS)是一种复杂的多因素疾病,尽管在生活方式管理和药物治疗方面取得了进展,但仍是心血管疾病高发病率和死亡率的主要原因。微小RNA(miRNAs)是一组小的单链非编码RNA,调节多种生理过程和分子信号传导途径。越来越多的研究证实miRNAs表达谱的改变在AS发生发展中发挥重要作用,本文综述了近年来miRNAs调控AS内皮细胞、血管平滑肌细胞,炎症反应和胆固醇代谢等过程的机制研究,并进一步讨论了miRNAs在AS诊断、疗效监测和预后判断生物标志物的价值。Atherosclerosis(AS)is a complex multifactorial disease that remains a major cause of high cardiovascular morbidity and mortality despite advances in lifestyle management and pharmacotherapy.MicroRNAs(miRNAs) are a group of small single-stranded noncoding RNAs that regulate a variety of physiological processes and molecular signaling pathways.More and more studies have confirmed that the expression profile of miRNAs plays an important role in the occurrence and development of AS.This article reviews the recent research on the mechanism of miRNAs regulating endothelial cells,vascular smooth muscle cells,inflammatory response and cholesterol homeostasis in AS,and further discusses the value of miRNAs as biomarkers in the diagnosis,efficacy monitoring,and prognosis of AS.

关 键 词：动脉粥样硬化 MIRNAS 炎症反应 胆固醇代谢 

分 类 号：R543.5[医药卫生—心血管疾病]