普米克令舒联合氨溴索雾化与丙种球蛋白治疗新生儿肺炎的效果  

Effect of pulmicresol combined with ambroxol aerosol and gamma globulin in the treatment of neonatal pneumonia

作　　者：陈华 谢影 白彦红 马兵兵 CHEN Hua;XIE Ying;BAI Yanhong;MA Bingbing(Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou,Hebei,China,075000)

机构地区：[1]张家口市妇幼保健院,河北张家口075000

出　　处：《分子诊断与治疗杂志》2023年第4期568-572,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省科技计划项目(202772781D)。

摘　　要：目的分析普米克令舒联合氨溴索雾化与丙种球蛋白治疗新生儿肺炎的效果及对血清C反应蛋白(CRP)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的影响。方法选取2020年5月至2022年10月张家口市妇幼保健院收治的新生儿肺炎患儿201例为研究对象,按照不同治疗方案分为对照组98例(普米克令舒+氨溴索)和实验组(普米克令舒+氨溴索+丙种球蛋白)103例。对比两组治疗效果、炎性因子(包括CRP、IL-8、TNF-α)、心肌酶谱[包括肌酸激酶(CK)、乳酸脱氢酶(LDH)及肌酸激酶同工酶(CK-MB)]、免疫球蛋白[免疫球蛋白-A(IgA)、免疫球蛋白-G(IgG)]及不良反应发生率。结果对照组总疗效占比79.59%,实验组总疗效占比96.11%,实验组总疗效占比高于对照组,差异具有统计学意义(P<0.05)。两组治疗后CRP、IL-8、TNF-α水平均出现下降,且实验组低于对照组,差异有统计学意义(P<0.05)。两组治疗后CK、LDH、CK-MB水平均出现下降,且实验组低于对照组,差异有统计学意义(P<0.05)。两组治疗后IgA、IgG水平均上升,且实验组高于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为6.12%,实验组不良反应发生率为2.91%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论普米克令舒联合氨溴索雾化与丙种球蛋白治疗新生儿肺炎治疗效果良好,可在一定程度上减轻患儿炎性反应,改善心肌酶谱,提高免疫功能,且安全性尚可,值得临床推广应用。Objective To analyze the effects of Pulmicort Lingshu combined with ambroxol nebulization and gamma globulin in the treatment of neonatal pneumonia and its influence on serum C-reactive protein(CRP),interleukin-8(IL-8),the tumor necrosis factor-alpha(TNF-α).Methods A total of 201 children with neonatal pneumonia admitted to Zhangjiakou Maternal and Child Health Care Hospital from May 2020 to October 2022 were selected as the research objects.According to different treatment regimens,they were divided into the control group(98 cases)(prmicrysol+ambroxol)and the experimental group(103 cases)(prmicrysol+ambroxol+gamma globulin).The therapeutic effect,inflammatory factors(including CRP,IL-8,TNF-α),myocardial enzyme profiles(including creatine kinase(CK),lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CK-MB)),immunoglobulin[IgA),immunoglobulin-G(IgG)]and incidence of adverse reactions were compared between the two groups.Results The total curative effect of the control group accounted for 79.59%,and the total curative effect of the experimental group accounted for 96.11%.The total curative effect of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of CRP,IL-8,and TNF-αin the two groups decreased,and the levels of CRP,IL-8,and TNF-αin the experimental group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CK,LDH,and CK-MB in the two groups decreased,and the levels of CK,LDH,and CK-MB in the experimental group were significantly lower than those in the control group(P<0.05).After treatment,the levels of IgA and IgG in the two groups increased,and the levels of IgA and IgG in the experimental group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 6.12%,and the incidence of adverse reactions in the expe

关 键 词：普米克令舒 氨溴索雾化 丙种球蛋白 新生儿肺炎 CRP IL-8 TNF-α 

分 类 号：R722.135[医药卫生—儿科]