围绝经期盆底肌功能障碍患者血清松弛素H2、LN和Fibulin-5变化及意义  

Changes and significance of serum relaxin H2,LN and fibulin-5 in perimenopausal patients with pelvic floor muscle dysfunction

作　　者：李云芳[1] 王小燕 勾明月 LI Yunfang;WANG Xiaoyan;GOU Mingyue(Department of Gynecology,Langfang People's Hospital,Langfang,Hebei,China,065000)

机构地区：[1]廊坊市人民医院妇科,河北廊坊065000

出　　处：《分子诊断与治疗杂志》2023年第4期598-601,共4页Journal of Molecular Diagnostics and Therapy

基　　金：廊坊市科学技术研究与发展计划(第二批)自筹经费项目(2020013110)。

摘　　要：目的 探讨围绝经期盆底肌功能障碍患者血清松弛素(H2)、层粘蛋白(LN)和细胞外基质糖蛋白(Fibulin-5)变化及意义。方法 选择2020年1月至2022年1月廊坊市人民医院收治的围绝经期盆底肌功能障碍患者80例作为研究对象,设为观察组,另选取本院同期体检的围绝经期盆底功能正常的妇女80名作为对照组,比较两组血清松弛素H2、LN、Fibulin-5和盆底肌力等级,分析血清松弛素H2、LN联合Fibulin-5对围绝经期盆底肌功能障碍的预测效能。结果 观察组患者的H2、LN均高于对照组,Fibulin-5水平低于对照组,差异有统计学意义(P<0.05)。对不同预后组间存在统计学差异的因素进行Logistic多因素分析后得到,H2、LN和Fibulin-5是影响围绝经期盆底肌功能障碍患者的相关危险因素(P<0.05)。盆底肌力与血清松弛素H2水平和LN水平呈负相关,与Fibulin-5水平呈正相关(P<0.05)。血清松弛素H2、LN和Fibulin-5诊断盆底肌功能障碍患者的效能较高,且Fibulin-5诊断盆底肌功能障碍患者的效能最高(P<0.05)。血清松弛素H2、LN联合Fibulin-5诊断盆底肌功能障碍患者AUC为0.937,敏感度、特异度分别为79.73%、93.33%。结论 围绝经期盆底肌功能障碍患者血清松弛素、LN水平升高,Fibulin-5水平降低,三者均与盆底肌功能存在一定关联性,联合预测盆底肌功能障碍的效能较好,值得临床推广。Objective To investigate the changes of serum relaxin(H2),laminin(LN)and extracellular matrix glycoprotein(Fibulin-5)in perimenopausal patients with pelvic floor muscle dysfunction.Methods Eighty cases of perimenopausal patients with pelvic floor muscle dysfunction admitted to Langfang People's Hospital from January 2020 to January 2022 were selected as the observation group,and 80 cases of perimenopausal women with normal pelvic floor function admitted to our hospital during the same period were selected as the control group.Serum relaxin H2,LN,Fibulin-5 and pelvic floor muscle strength levels of the two groups were compared,and the predictive efficacy of serum relaxin H2 and LN combined with Fibulin-5 on perimenopausal pelvic floor muscle dysfunction was analyzed.Results The levels of H2 and LN in the observation group were higher than those in the control group,but Fibulin-5 was lower,the difference was statistically significant(P<0.05).Logistic multivariate analysis of the factors with statistical difference between different prognostic groups showed that H2,LN and Fibulin-5 were the risk factors affecting perimenopausal patients with pelvic floor muscle dysfunction(P<0.05).Pelvic floor muscle strength was negatively correlated with serum relaxin H2 level and LN level,and positively correlated with Fibulin-5 level(P<0.05).Serum relaxin H2,LN and Fibulin-5 showed high efficacy in the diagnosis of patients with pelvic floor muscle dysfunction,and Fibulin-5 had the highest efficacy in the diagnosis of patients with pelvic floor muscle dysfunction(P<0.05).The AUC of patients with pelvic floor muscle dysfunction diagnosed by serum relaxin H2 and LN combined with Fibulin-5 was 0.937,and the sensitivity and specificity were 79.73% and 93.33%,respectively.Conclusion The levels of serum relaxin and LN were increased and the levels of Fibulin-5 were decreased in perimenopausal patients with pelvic floor muscle dysfunction.There is a certain correlation between the three levels and pelvic floor muscle function.The combi

关 键 词：围绝经期 盆底肌功能障碍 血清松弛素 层粘蛋白 细胞外基质糖蛋白 

分 类 号：R711.5[医药卫生—妇产科学]