血清补体1q、同型半胱氨酸及脂联素水平在老年原发性高血压并发心血管疾病风险评估中的价值  

The value of serum complement 1q,homocysteine and adiponectin levels in the risk assessment of elderly patients with essential hypertension with cardiovascular disease

作　　者：汤祥瑞 程德均 王科程 郭宏毅 张勇[2] TANG Xiangrui;CHENG Dejun;WANG Kecheng;GUO Hongyi;ZHANG Yong(Department of Cardiovascular Medicine,3201 Affiliated Hospital of Xi'an Jiaotong University,Hanzhong,Shaanxi,China,723000;Department of Cardiology,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi,China,710068)

机构地区：[1]西安交通大学附属三二○一医院心血管内科,陕西汉中723000 [2]陕西省人民医院心血管内一科,陕西西安710068

出　　处：《分子诊断与治疗杂志》2023年第4期602-605,609,共5页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省科学基金项目(2018-SF2-10)。

摘　　要：目的 通过分析血清补体1q(C1q)、同型半胱氨酸(Hcy)及脂联素(APN)的水平,探讨这些指标在老年原发性高血压并发心血管疾病风险评估中的价值。方法 选择2020年3月至2022年3月西安交通大学附属三二〇一医院收治的原发性高血压并发心血管疾病患者154名作为高血压并心血管疾病组,另选取同期于本院收治的高血压患者151例为单纯高血压组,同期体检健康者152例为对照组,观察三组及原发性高血压并发心血管疾病患者高风险与低风险组血清Hcy、APN、C1q水平,分析影响老年原发性高血压并发心血管疾病风险的相关因素。结果 APN、C1q水平:高血压并心血管疾病组<单纯高血压组<对照组μg/mL,Hcy水平:高血压并心血管疾病组>单纯高血压组>对照组,差异有统计学意义(P<0.05);高风险组的血清APN、C1q水平分别为(12.34±2.87)mg/L、(164.47±8.65)μg/mL,低于低风险组的(25.69±1.25)mg/L、(171.39±9.26)μg/mL,Hcy水平为(24.78±4.74)mg/L,高于低风险组的(17.54±2.85)mg/L,差异有统计学意义(P<0.05);收集所有研究者基线资料、生化指标,经非条件多因素logistic回归模型分析得,吸烟史、糖尿病史、高血压史、体重指数、病理分级、危险度的分层、Hcy、APN、C1q为原发性高血压并发心血管疾病风险的独立危险因素(P<0.05)。结论 血清Hcy、APN、C1q水平在评估老年原发性高血压并发心血管疾病风险方面具有较高的价值,有望作为老年原发性高血压并发心血管疾病中的生物标志物。Objective To explore the value of these indicators in the risk assessment of elderly patients with essential hypertension complicated with cardiovascular disease by analyzing the levels of serum complement 1q(C1q),homocysteine(Hcy)and adiponectin(APN).Methods From March 2020 to March 2022,154 patients with essential hypertension complicated with cardiovascular disease admitted to the 3201 Hospital Affiliated to Xi'an Jiaotong University were selected as the hypertension complicated with cardiovascular disease group.151 cases of hypertensive patients belonged to the simple hypertension group,and 152 cases of healthy people who underwent physical examination during the same period were used as the control group.The levels of serum Hcy,APN,and C1q in the three groups and the high-risk and low-risk groups of patients with essential hypertension complicated by cardiovascular disease were observed.The related factors affecting the risk of elderly primary hypertension and cardiovascular disease were analyzed.Results APN,C1q level:hypertension with cardiovascular disease group<simple hypertension group<control groupμg/mL,Hcy level:hypertension with cardiovascular disease group>simple hypertension group>control group,the difference was statistically significant(P<0.05).The serum APN and C1q levels in the high-risk group were(12.34±2.87)mg/L and(164.47±8.65)μg/mL,respectively,which were lower than those in the low-risk group(25.69±1.25)mg/L and(171.39±9.26)μg/mL,the Hcy level was(24.78±4.74)mg/L,which was higher than that in the low-risk group(17.54±2.85)mg/L,and the difference was statistically significant(P<0.05).The baseline data and biochemical indicators of all the researchers were collected and analyzed by unconditional multivariate logistic regression model.The results showed that smoking history,diabetes history,hypertension history,body mass index,pathological grade,risk stratification,Hcy,APN,C1q were independent risk factors for essential hypertension complicated with cardiovascular disease(P<0.05).Conc

关 键 词：血清补体1q 同型半胱氨酸 脂联素 原发性高血压并发心血管疾病 

分 类 号：R544.1[医药卫生—心血管疾病]