高血压病患者外周血Cx43、Ang2表达及意义  

Expression and significance of Cx43 and Ang2 in peripheral blood of patients with hypertension

作　　者：张金春 李志华 ZHANG Jinchun;LI Zhihua(Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai,China,202150)

机构地区：[1]上海健康医学院附属崇明医院,上海202150

出　　处：《分子诊断与治疗杂志》2023年第4期610-613,617,共5页Journal of Molecular Diagnostics and Therapy

基　　金：上海市崇明区“可持续发展科技创新行动计划”项目(CKY2019-11)。

摘　　要：目的探究高血压病患者外周血间隙连接蛋白43(Cx43)、促血管生成素2(Ang2)表达与血压控制的关系。方法选取上海健康医学院附属崇明医院210例高血压患者为研究组,同期随机选取于本院进行健康体检的非高血压人群240名作为对照组,检测外周血Cx43、Ang2水平。分析Cx43、Ang2水平与其他指标及血压的关系。结果研究组收缩压(SBP)、舒张压(DBP)、左心室质量指数(LVMI)、糖化血红蛋白(HbA1c)、白介素-6(IL-6)、C反应蛋白(CRP)、低密度脂蛋白胆固醇(LDL-C)、Ang2水平高于对照组,差异有统计学意义(P<0.05),高密度脂蛋白胆固醇(HDL-C)、Cx43水平低于对照组,差异有统计学意义(P<0.05)。治疗后3、6个月时,高血压病患者外周血Cx43水平逐渐升高,均高于入组时水平,差异有统计学意义(P<0.05),Ang2、LVMI、总胆固醇(TC)、甘油三酯(TG)水平、白天、夜间及24 h收缩压(d SBP、nSBP、24 hSBP),白天、夜间及24 h舒张压(dDBP、nDBP、24 hDBP)逐渐降低,均低于入组时水平,差异有统计学意义(P<0.05);入组时和治疗后6个月时,血压正常人数比例与血压1级、2级、3级人数比例差异有统计学意义(P<0.05)。高血压病患者外周血Ang2水平与IL-6、CRP、LVMI及血压指标呈正相关(P<0.05)。结论Cx43和Ang2水平可反映血管收缩舒张功能,且高血压病患者血压控制不良与外周血Cx43水平降低,Ang2水平升高有关。Objective To explore the relationship between the expressions of connexin 43(Cx43)and angiopoietin 2(Ang2)and blood pressure control in patients with hypertension.Methods 210 patients with hypertension were selected as the study group,and 240 non-hypertensive patients who underwent physical examination in our hospital were randomly selected as the control group during the same period.The level of Cx43 and Ang2 in peripheral blood were detected.The relationship between Cx43,Ang2 levels and other indexes and blood pressure were compared.Results The levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),Left ventricular mass index(LVMI),glycosylated hemoglobin(HbA1c),interleukin-6(IL-6),C-reactive protein(CRP),low-density lipoprotein cholesterol(LDL-C)and Ang2 in the study group were higher than those in the control group(P<0.05).The level of high-density lipoprotein cholesterol(HDL-C)and Cx43 were lower than those in the control group(P<0.05).At 3 and 6 months after treatment,the level of peripheral blood Cx43 in hypertensive patients gradually increased,all of which were higher than those at enrollment,and the difference was statistically significant(P<0.05).The levels of Ang2,LVMI,total cholesterol(TC),triglycerides(TG),dSBP,nSBP,24 hSBP,dDBP,nDBP and 24 hDBP gradually decreased,all lower than those at enrollment(P<0.05).At enrollment and 6 months after treatment,there were statistically significant differences in the proportion of people with normal blood pressure and the proportion of people with blood pressure grade 1,2 and 3(P<0.05).Peripheral blood Ang2 levels in patients with hypertension were positively correlated with IL-6,CRP,LVMI and blood pressure indicators(P<0.05).Conclusion The levels of Cx43 and Ang2 can reflect the vasoconstriction and relaxation function,and the poor control of blood pressure in patients with hypertension is related to the decrease of peripheral blood Cx43 level and the increase of Ang2 level.

关 键 词：高血压病 间隙连接蛋白43 促血管生成素2 

分 类 号：R544.1[医药卫生—心血管疾病]