银屑病患者1,25(OH)_(2)D_(3)与炎性因子水平关系及阿维A联合NB-UVB疗效观察  

Relationship between 1,25(OH)_(2)D_(3) and inflammatory factors in patients with psoriasis and the efficacy of acitretin combined with NB-UVB

作　　者：李颖慧 郭芳 杨改娥 LI Yinghui;GUO Fang;YANG Gaie(Pediatrics of Shanxi Yuncheng Central Hospital,Yuncheng,Shanxi,China,044000)

机构地区：[1]山西省运城市中心医院儿科,山西运城044000

出　　处：《分子诊断与治疗杂志》2023年第4期716-719,724,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山西省科技计划项目(20210345)。

摘　　要：目的 探讨银屑病患者血清1,25-二羟基维生素D_(3)[1,25(OH)_(2)D_(3)]与炎性因子水平关系及阿维A联合窄谱中波紫外线(NB-UVB)方案的疗效。方法 选取2020年1月至2021年11月在山西省运城市中心医院治疗的银屑病患者109例作为观察组,同时选取100名健康者作为对照组,根据病历号末尾奇偶数将观察组患者分为观察A组(n=57)和观察B组(n=52),其中观察A组给予阿维A联合NB-UVB治疗,观察B组给予NB-UVB治疗,对比观察两组治疗疗效。结果 观察组血清1,25(OH)_(2)D_(3)明显低于对照组,差异有统计学意义(t=-16.614,P<0.05),而白细胞计数(WBC)、中性粒细胞/淋巴细胞比(NLR)、血小板/淋巴细胞比(PLR)、C反应蛋白(CRP)和肿瘤坏死因子a(TNF-a)明显高于对照组,差异有统计学意义(t=12.832、5.869、8.678、26.944、19.084,P<0.05)。观察组中重度患者血清1,25(OH)_(2)D_(3)明显低于轻度患者,差异有统计学意义(t=2.699,P<0.05),而NLR和PLR明显高于轻度患者,差异有统计学意义(t=-5.141、-3.719,P<0.05)。结论 银屑病患者血清1,25(OH)_(2)D_(3)与NLR和PLR呈负相关,同时与患者病情程度呈负相关;阿维A联合NB-UVB治疗银屑病有较好的疗效,明显改善患者生活质量。Objective To investigate the relationship between serum 1,25-dihydroxyvitamin D_(3)[1,25(OH)_(2)D_(3)]and inflammatory factors in patients with psoriasis,and to observe the efficacy of acitretin combined with narrow-spectrum ultraviolet B(NB-UVB).Methods 109 patients with psoriasis treated in Shanxi Yuncheng Central Hospital from January 2020 to November 2021 were selected as the observation group and 100 healthy person as the control group,according to the odd and even number at the end of the medical record number,the patients in the observation group were divided into observation group A(n=57)and observation group B(n=52),the observation group A was treated with Avia combined with NB-UVB,and the observation group B was treated with NB-UVB,the therapeutic efficacy between the two groups were observed.Results Serum 1,25(OH)_(2)D_(3) in the observation group was significantly lower than that in the control group,the difference was statistically significant(t=-16.614,P<0.05),while leukocyte count(WBC),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),C-reactive protein(CRP)and tumor necrosis factor a(TNF-a)in the observation group were significantly higher than those in the control group,the difference was statistically significant(t=12.832,5.869,8.678,26.944,19.084,P<0.05).Serum 1,25(OH)_(2)D_(3) in moderate and severe patients in the observation group was significantly lower than that in mild patients,the difference was statistically significant(t=2.699,P<0.05),while NLR and PLR were significantly higher than those in mild patients,the difference was statistically significant(t=-5.141,3.719,P<0.05).Conclusion Serum 1,25(OH)_(2)D_(3) in patients with psoriasis is negatively correlated with NLR and PLR,and negatively correlated with the degree of disease.Acitretin combined with NB-UVB is effective in the treatment of psoriasis and significantly improves the lives of patient quality.

关 键 词：银屑病 血清1 25-二羟基维生素D_(3) 炎性因子 阿维A 窄谱中波紫外线 疗效 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]