纳秒脉冲电场治疗黑色素瘤的前景  

Prospect of Nanosecond Pulsed Electric Field in the Treatment of Melanoma

作　　者：王泽伟 姚成俊 董延钊 周海英 Ahmad Alhaskawi 李鹏飞[2] 涂田 陈永刚 卢荟[1] WANG Zewei;YAO Chengjun;DONG Tingzao;ZHOU Haiying;Ahmad Alhaskawi;LI Pengfei;TU Tian;CHEN Yonggang;LU Hui(Division of Orthopedics,Zhejiang University School of Medicine,Hangzhou Zhejiang 310003,China;Division of Plastic and Aesthetic,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310003,China;Zhejiang Provincial Key Laboratory of Pulsed Power Translational Medicine,Hangzhou Zhejiang 311100,China)

机构地区：[1]浙江大学医学院附属第一医院骨科,浙江杭州310003 [2]浙江大学医学院附属第一医院整形美容科,浙江杭州310003 [3]浙江省脉冲电场技术医学转化重点实验室,浙江杭州311100

出　　处：《中国医疗设备》2023年第5期70-74,85,共6页China Medical Devices

基　　金：国家自然科学基金(2027803,82070516,82102183)。

摘　　要：作为一种新型的治疗手段,纳秒脉冲电场(Nanosecond Pulse Electric Field,nsPEF)在黑色素瘤治疗中显示出了良好的应用前景。本文综述了nsPEF治疗黑色素瘤在细胞实验、动物实验与人体实验方面的研究进展,指出了nsPEF可通过多种机制诱导黑色素瘤消融,并产生长期抗肿瘤记忆抑制其复发转移,同时具有高度靶向效果,不产生额外热损伤。这些独特优势对于黑色素瘤治疗具有广阔的临床应用前景,为临床治疗黑色素瘤提供了新的思路。As a novel therapeutic tool,nanosecond pulsed electric field(nsPEF)has shown promising applications in melanoma treatment.This paper reviews the research progress of nsPEF in the treatment of melanoma in cell experiments,animal experiments and human experiments,and points out that nanosecond pulsed electric field can induce melanoma ablation through various mechanisms and produce long-term anti-tumor memory to inhibit its recurrence and metastasis,while having highly targeted effect without additional thermal damage.These unique advantages have broad clinical application prospects for melanoma treatment and provide new ideas for clinical treatment of melanoma.

关 键 词：不可逆电穿孔 纳秒脉冲电场 消融 黑色素瘤 

分 类 号：R197.39[医药卫生—卫生事业管理]