3-烷氧基-3-烷基异吲哚啉-1-酮的合成  

Synthesis of 3-Alkoxy-3-alkyl-isoindoline-1-ones

作　　者：龙燕 农莉冕 万代煜 贺方兰 张晓梅 LONG Yan;NONG Limian;WAN Daiyu;HE Fanglan;ZHANG Xiaomei(Department of Chemistry,Xihua University,Chengdu 610039,China;Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China)

机构地区：[1]西华大学化学系,四川成都610039 [2]中国科学院成都有机化学研究所,四川成都610041

出　　处：《合成化学》2023年第5期329-339,共11页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：为探索3-亚烷基异吲哚啉-1-酮在有机合成中的应用潜力,构建新型的异吲哚啉-1-酮类化合物,本文以3-亚烷基异吲哚啉-1-酮和醇为原料,在三氯硅烷与路易斯碱催化剂作用下发生加成反应,得到一系列3-烷氧基-3-烷基异吲哚啉-1-酮类化合物,并初步尝试了以手性路易斯碱催化该反应。综上,本文建立了一种新型异吲哚啉-1-酮类化合物的合成方法,该方法条件具有温和、操作便捷、底物适用范围广和收率普遍较高的特点。In order to explore the potential of 3-alkyleneisoindoline-1-ones in organic synthesis and construct new isoindoline-1-one derivatives,addition of 3-alkyleneisoindoline-1-ones with alcohols was conducted in the presence of trichlorosilane and Lewis base catalyst.A wide variety of 3-alkoxy-3-alkyl-isoindoline-1-ones were prepared by this transformation.Moreover,a catalytic asymmetric version of this reaction was explored.In brief,a method of preparation of new isoindoline-1-one derivatives has been established.This method features mild conditions,easy handling,wide substrate tolerance and generally good yields.

关 键 词：3-亚烷基异吲哚啉-1-酮 3-烷氧基-3-烷基异吲哚啉-1-酮 合成工艺 路易斯碱催化剂 波谱鉴定 

分 类 号：O626.29[理学—有机化学]