新型亲电三氟甲硫基化试剂的制备和应用  

Preparation and Application of Novel Electrophilic Tifluoromethylthiolation Reagent

作　　者：冯瑞龙 蒋超 赵奎 魏崇滨 陈锡飞 郑昌戈 洪建权 FENG Ruilong;JIANG Chao;ZHAO Kui;WEI Chongbin;CHEN Xifei;ZHENG Changge;HONG Jianquan(School of chemical and Material Engineering,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《合成化学》2023年第5期356-361,共6页Chinese Journal of Synthetic Chemistry

基　　金：中央高校基本科研业务项目(JUSRP22020)。

摘　　要：芳基三氟甲基硫醚化合物在药物、农用化学品和材料科学等领域具有重要的应用。本文报道了一种新型亲电三氟甲硫基化试剂的合成方法,并分别与芳基硼酸和吲哚类化合物反应,都以60%~95%的产率得到相应的目标产物化合物11和化合物13,其结构经_(1)H NMR、^(19)F NMR、^(13)C NMR和HR-MS确证。该试剂可作为对现有亲电三氟甲硫基化试剂的补充,为化学工作者以及药物化学工作者方便快捷地引入三氟甲硫基团提供了一种新的工具。Aryl trifluoromethyl thioethers have significant applications in medicine,agricultural chemicals and materials science.Herein,the synthesis of a new type of electrophilic trifluoromethylthiolation reagent and its reaction with aryl borate or indole derivatives are reported,with the corresponding targets 11 or 13 obtained in 60%~95%yield,which have been confirmed by^(1)H NMR,^(19)F NMR,^(13)C NMR and HR-MS.As a significant extension to the current electrophilic trifluoromethylthiolation reagent,this reagent provides a new tool for chemists and pharmaceutical chemists to conveniently and concisely introduce trifluoromethylthio group into the organic compounds.

关 键 词：三氟甲硫基化 亲电型 芳基硼酸 吲哚 合成 

分 类 号：O625.72[理学—有机化学] O622.7[理学—化学]