钯催化氟代偕二醇的芳基化反应  

Palladium-catalyzed Arylation of Fluorinated Gem-Diols

作　　者：徐利军 李若阳 罗艳红 徐金球[1] XU Lijun;LI Ruoyang;LUO Yanhong;XU Jinqiu(Shanghai Engineering Research Center of Advanced Thermal Functional Materials,School of Resources and Environmental Engineering,Shanghai Polytechnic University,Shanghai 201209,China)

机构地区：[1]上海第二工业大学资源与环境工程学院上海先进热功能材料工程技术研究中心,上海201209

出　　处：《合成化学》2023年第5期368-375,共8页Chinese Journal of Synthetic Chemistry

基　　金：上海市青年科技英才扬帆计划(19YF1416500);上海第二工业大学校基金资助项目(EGD19XQD17、EGD22DS09)。

摘　　要：以醋酸钯、1,1’-联萘-2,2’-双二苯膦(BINAP)为催化剂,二甲苯为溶剂,氟代偕二醇砌块在碳酸钾的作用下,脱三氟乙酸后与溴代芳烃发生芳基化反应,于130℃反应7 h,合成了一系列α-氟代芳基酮类化合物,收率最高可达96%,其结构经^(1)H NMR,^(13)C NMR,^(19)F NMR和HR-MS(ESI)表征。A series ofα-fluorinated arones were synthesized by arylation of fluorinated gem-diols catalyzed by Pd(OAc)_(2)and 1,1’-binaphthyl-2,2’-diphemyl phosphine(BINAP)in xylene at 130℃for 7 h,and using K_(2)CO_(3)as the base.The yields of products were up to 96%.The structures of compounds were characterized by^(1)H NMR,^(13)C NMR,^(19)F NMR and HR-MS(ESI).

关 键 词：钯催化 芳基化 α-氟代芳基酮 1 1’-联萘-2 2’-双二苯膦 含氟砌块 

分 类 号：O62[理学—有机化学]