微生态疗法在新生儿黄疸治疗中的疗效观察  

Curative Effect Observation of Microecological Therapy on Treatment of Neonatal Jaundice

作　　者：钱月芳 高兰平[1] 张文英[1] 洪丹 王芳[1] QIAN Yuefang;GAO Lanping;ZHANG Wenying;HONG Dan;WANG Fang(Pediatrics Department,Suzhou City Wuzhong People's Hospital,Suzhou,Jiangsu 215000)

机构地区：[1]江苏省苏州市吴中人民医院儿科,江苏苏州215000

出　　处：《智慧健康》2023年第5期130-134,共5页Smart Healthcare

摘　　要：目的 观察微生态疗法在新生儿黄疸治疗中的疗效。方法 选200例15d龄初生新生儿。入组条件:足月儿,日龄15d,出生体重>2500g,无异常分娩史,单纯母乳喂养儿,经皮测胆红素12.0~15.0mg/dl入组。治疗组:100例选择口服丽珠肠乐(双歧杆菌活菌制剂),每隔3d复测一次;对照组:100例选择日光照射治疗,每隔3d复测1次,2组治疗后经皮测胆红素<5.0mg/dl均停止治疗,对两组患儿临床疗效、血清指标水平、不良反应发生情况进行观察比较。结果 治疗组、对照组两组患儿黄疸治愈率,经统计学处理,差异有显著性(P<0.01)。治疗组治疗后TBIL水平、DBIL水平、IBIL水平均明显低于对照组,差异有显著性(P<0.05)。两组患儿不良反应发生率对比无显著性差异(P>0.05)。结论 微生态疗法对于>2周的足月新生儿(除外先天性胆道闭锁等先天性疾病患儿),一般情况好,经皮胆红素在12~15mg/di的黄疸患儿治疗,简单、经济、安全、有效,值得推广。Objective To observe curative effect of microecological therapy in treatment of neonatal jaundice.Methods The paper chose 200 newborns aged 15 days with admission conditions fo term infants,15 days old,birth weight>2500g,without abnormal delivery history,exclusively breastfed infants,with percutaneous bilirubin measurement of 12.0-15.0mg/dl,excluding children with congenital diseases such as biliary atresia.Treatment group:100 cases taking oral Lizhu Changle(bifidobacterium viable preparation)for retesting every 3 days;control group:100 cases with solar irradiation treatment and retested every 3 days.After treatment,treatment of both groups was stopped with transcutaneous bilirubin measurement of<5.0mg/dl.Clinical effect,serum index levels and adverse reactions between two groups were observed and compared.Results There was significant difference in cure rate of jaundice between treatment group and control group(P<0.01).After treatment,levels of TBIL,DBIL,and IBIL in treatment group were significantly lower than control group(P<0.05).There was no significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Microecological therapy is generally good for term newborns>2 weeks old(excluding children with congenital diseases such as biliary atresia),being simple,economical,safe,and effective for children with jaundice whose transcutaneous bilirubin is between 12 and 15 mg/dL,which is worthy of promoton.

关 键 词：微生态疗法 新生儿黄疸 先天性胆道闭锁 双歧杆菌活菌制剂 日光照射治疗 

分 类 号：R722.17[医药卫生—儿科]