雷公藤多苷片联合双氯芬酸钠缓释片治疗类风湿性关节炎临床研究  

Clinical Study on Tripterygium Glycosides Tablets Combined with Diclofenac Sodium Sustained-Release Tablets for Rheumatoid Arthritis

作　　者：徐敏 张忆勇 俞芳 XU Min;ZHANG Yiyong;YU Fang

机构地区：[1]浙江省医疗健康集团长兴医院药剂科,浙江湖州313117 [2]浙江省医疗健康集团长兴医院骨科,浙江湖州313117

出　　处：《新中医》2023年第8期121-124,共4页New Chinese Medicine

摘　　要：目的:观察雷公藤多苷片联合双氯芬酸钠缓释片治疗类风湿性关节炎的临床疗效。方法:按照随机数字表法将68例类风湿性关节炎患者分为对照组与治疗组各34例。对照组采取双氯芬酸钠缓释片口服治疗;治疗组在对照组的基础上联合雷公藤多苷片治疗。比较2组治疗前后症状体征改善情况、血清学指标[C-反应蛋白(CRP)、抗环瓜氨酸肽抗体(ACCP)、类风湿因子(RF)、抗链球菌溶血素O (ASO)]水平变化,并统计临床疗效及不良反应发生率。结果:治疗组总有效率为97.06%,对照组为79.41%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组肿胀关节数、压痛关节数、晨僵时间、疼痛视觉模拟评分法(VAS)评分均较治疗前改善(P<0.05),且治疗组上述各项症状体征改善均优于对照组(P<0.05)。治疗后,2组血清RF、ASO、CRP、ACCP水平均较治疗前降低,且治疗组上述各项指标均低于对照组(P<0.05)。治疗期间,治疗组不良反应发生率为5.88%,对照组为11.76%,2组比较,差异无统计学意义(P>0.05)。结论:雷公藤多苷片联合双氯芬酸钠缓释片治疗类风湿性关节炎效果显著,可改善患者临床症状体征与关节功能,减轻疼痛,下调节炎性因子及RF水平,且不良反应相对较少。Objective:To observe the clinical effect of Tripterygium Glycosides Tablets combined with Diclofenac Sodium Sustained-Release Tablets for rheumatoid arthritis.Methods:A total of 68 cases of rheumatoid arthritis were divided into the control group and the treatment group according to the random number table method,with 34 cases in each group.The control group was given the oral administration of Diclofenac Sodium Sustained-Release Tablets,and the treatment group was additionally treated with Tripterygium Glycosides Tablets based on the treatment of the control group.The improvement of symptoms and signs,and the changes in levels of serological indexes including C-reactive protein(CRP),anti-cyclic citrullinated peptide antibody(ACCP),rheumatoid factors(RF),and anti-streptolysin O(ASO)were compared between the two groups before and after treatment.Clinical effects and the incidence of adverse reactions were counted.Results:The total effective rate was 97.06%in the treatment group and 79.41%in the control group,the difference being significant between the two groups(P<0.05).After treatment,the number of swollen joints,the number of tenderness joints,the duration of morning stiffness,and Visual Analogue Scale (VAS) scores in the two groups were decreased when compared withthose before treatment (P<0.05),and the above indexes of symptoms and signs in the treatment groupwere lower than those in the control group (P<0.05). After treatment,the levels of RF,ASO,CRP,andACCP in serum in the two groups were decreased when compared with those before treatment,and theabove indexes in the treatment group were lower than those in the control group (P<0.05). Duringtreatment,the incidence of adverse reactions was 5.88% in the treatment group and 11.76% in the controlgroup, there being no significance in the difference between the two groups (P>0.05). Conclusion:Tripterygium Glycosides Tablets combined with Diclofenac Sodium Sustained- Release Tablets has asignificant curative effect in the treatment of rheumatoid arthritis, and can

关 键 词：类风湿性关节炎 雷公藤多苷片 双氯芬酸钠缓释片 类风湿因子 抗环瓜氨酸肽抗体 

分 类 号：R593.23[医药卫生—内科学]