槐杞黄颗粒联合西药治疗小儿紫癜性肾炎临床研究  

Clinical Study on Huaiqihuang Granules Combined with Western Medicine for Children with Purpura Nephritis

作　　者：应琴[1] 周先富[1] 叶鑫[1] YING Qin;ZHOU Xianfu;YE Xin

机构地区：[1]衢州市人民医院,浙江衢州324000

出　　处：《新中医》2023年第8期134-138,共5页New Chinese Medicine

摘　　要：目的:观察槐杞黄颗粒联合西药治疗小儿紫癜性肾炎的临床疗效。方法:纳入74例气阴两虚型紫癜性肾炎患儿,采用随机数字表法分成治疗组和对照组各37例。2组均给予醋酸泼尼松龙片、硫唑嘌呤片治疗,治疗组联合槐杞黄颗粒治疗,连续治疗3个月。治疗前及治疗3个月后检测尿沉渣红细胞计数、24 h尿蛋白定量、免疫功能指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比值]、纤维蛋白原(FIB)及血管细胞黏附分子-1(VCAM-1)。观察治疗期间2组患儿的不良反应发生情况。比较2组的临床疗效。结果:治疗3个月,治疗组临床疗效总有效率高于对照组(P<0.05)。2组CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)比值与治疗前相比均升高(P<0.05),CD8^(+)水平与治疗前相比均下降(P<0.05);治疗组CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)比值均高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。2组尿沉渣红细胞计数、24 h尿蛋白定量及FIB、VCAM-1水平与治疗前相比均降低(P<0.05),治疗组尿沉渣红细胞计数、24 h尿蛋白定量及FIB、VCAM-1水平均低于对照组(P<0.05)。用药期间2组患儿均未见明显不良反应。结论:槐杞黄颗粒联合醋酸泼尼松龙片、硫唑嘌呤片治疗气阴两虚型小儿紫癜性肾炎临床疗效确切,可显著提高患儿的免疫力,减轻炎症损伤,改善体内血液高凝状态,进一步保护肾脏,且未见明显不良反应。Objective:To observe the clinical effect of Huaiqihuang Granules combined with western medicine for children with purpura nephritis.Methods:A total of 74 cases of children with purpura nephritis of deficiency of qi and yin type were included and divided into the treatment group and the control group according to the random number table method,with 37 cases in each group.Both groups were treated with Prednisolone Acetate Tablets and Azathioprine Tablets,and the treatment group was additionally treated with Huaiqihuang Granules.Both groups were treated for 3 months.Before treatment and after 3-month treatment,red blood cell counts in urine sediment,24-hour urinary protein quantification,immune function indexes including CD3^(+),CD4^(+),CD8^(+)and the ratio of CD4^(+)/CD8^(+),fibrinogen(FIB)and vascular cell adhesion molecule-1(VCAM-1)were detected.During treatment,the incidence of adverse reactions in the two groups was observed.The clinical effects in the two groups were compared.Results:After 3-month treatment,the total effective rate in the treatment group was higher than that in the control group(P<0.05).The levels of CD3^(+),CD4^(+)and the ratio of CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment(P<0.05),and the levels of CD8^(+)were decreased when compared with those before treatment(P<0.05).The levels of CD3^(+),CD4^(+)and the ratio of CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group(P<0.05),and the level of CD8^(+)was lower than that in the control group(P<0.05).Red blood cell counts in urine sediment,values of 24-hour urinary protein quantification and levels of FIB and VCAM-1 in the two groups were decreased when compared with those before treatment(P<0.05);the red blood cell count in urine sediment,the value of 24-hour urinary protein quantification and the levels of FIB and VCAM-1 in the treatment group were lower than those in the control group(P<0.05).During medication,no obvious adverse reaction was observed in the two groups.C

关 键 词：紫癜性肾炎 儿童 气阴两虚证 槐杞黄颗粒 免疫功能 纤维蛋白原 血管细胞黏附分子-1 

分 类 号：R726.9[医药卫生—儿科]