玻璃体腔注射康柏西普对糖尿病视网膜病变患者眼部血管及血流的影响  

Effects of Intravitreal Injection of Conbercept on ocular BloodVessels and Blood Flow in Patients with Diabetes Retinopathy

作　　者：李佳佳[1] LI Jiajia(Department of Ophthalmology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450004,China)

机构地区：[1]郑州大学第二附属医院眼科,河南郑州450004

出　　处：《临床研究》2023年第6期30-32,共3页Clinical Research

摘　　要：目的 研究糖尿病视网膜病变(DR)采取玻璃体腔注射康柏西普对眼部血管及血流的影响。方法 回顾性分析郑州大学第二附属医院2020年5月至2022年5月收治的60例(120眼)DR患者,其中对照组30例(60眼)予以视网膜激光光凝治疗,研究组30例(60眼)予以玻璃体腔注射康柏西普,观察两组视力、视网膜神经纤维层(RNFL)厚度、视网膜中央动脉(CRA)的血流动力学以及并发症情况。结果 治疗前两组视力、RNFL厚度、CRA的血流动力学差异无统计学意义(P> 0.05),研究组治疗后14 d、治疗后28 d视力高于对照组,差异有统计学意义(P <0.05)。研究组治疗后28 d RNFL厚度低于对照组,差异有统计学意义(P <0.05)。研究组并发症发生率(6.67%)低于对照组(20.00%),差异有统计学意义(P <0.05)。研究组治疗后28 d收缩期峰值流速(PSV)、阻力指数(RI)水平高于对照组,搏动指数(PI)水平低于对照组,差异有统计学意义(P <0.05)。结论 玻璃体腔注射康柏西普对于糖尿病视网膜病变治疗效果理想,能够使RNFL厚度下降,提升患者视力,对血流动力学有积极影响,降低并发症发生率,值得临床应用。Objective To study the effect of intravitreal injection of Conbercept on ocular blood vessels and blood flow in diabetes retinopathy(DR).Methods A total of 60 cases(120 eyes)of DR patients admitted to the Second Affiliated Hospital of Zhengzhou University from May 2020 to May 2022 were retrospectively analyzed.Among them,30 cases(60 eyes)in the control group were treated with retinal laser photocoagulation,and 30 cases(60 eyes)in the study group were treated with intravitreal injection of Conbercept.The visual acuity,retinal nerve fiber layer(RNFL)thickness,hemodynamics of central retinal artery(CRA),and complications of the two groups were observed.Results There was no statistically significant difference in visual acuity,RNFL thickness,and CRA hemodynamics between the two groups before treatment(P>0.05).The visual acuity of the study group was higher than that of the control group on the 14th and 28th days after treatment,with a statistically significant difference(P<0.05).The RNFL thickness in the study group was lower than that in the control group at 28 days after treatment,with a statistically significant difference(P<0.05).The incidence of complications in the study group(6.67%)was lower than that in the control group(20.00%),with a statistically significant difference(P<0.05).The study group had higher levels of peak systolic flow velocity(PSV)and resistance index(RI)at 28 days after treatment compared to the control group,while the pulsatile index(PI)level was lower than the control group,with statistically significant differences(P<0.05).Conclusion Intravitreal injection of Conbercept has an ideal therapeutic effect on diabetes retinopathy.It can reduce the thickness of RNFL,improve patients'vision,have a positive impact on hemodynamics,reduce the incidence of complications,and is worthy of clinical application.

关 键 词：玻璃体腔注射 康柏西普 糖尿病视网膜病变 眼部血管血流 

分 类 号：R587.2[医药卫生—内分泌]