基于数据挖掘与隐含狄利克雷分布的肿瘤化疗相关性口腔溃疡的中医用药规律  

Clinical Medication Rules of Traditional Chinese Medicine Against Oral Ulcer Induced by Tumor Chemotherapy Based on Data Mining and Latent Dirichlet Allocation

作　　者：李奕 罗富锟 张曦元 恩格尔 庞博[3] 花宝金[1] 朴炳奎[1] LI Yi;LUO Fukun;ZHANG Xiyuan;EN Geer;PANG Bo;HUA Baojin;PIAO Bingkui(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China;International Medical Department,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029 [3]中国中医科学院广安门医院国际医疗部,北京100053

出　　处：《世界中医药》2023年第9期1292-1297,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81873399)——基于原型范畴理论名老中医诊治肺癌认知模型优化研究;首都卫生发展科研专项青年优才项目(2018-4-4154)——基于循证思路朴炳奎诊治肿瘤学术思想与经验传承研究;全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号)。

摘　　要：目的:研究近20年恶性肿瘤化疗相关性口腔溃疡中医临床常用治疗方法及遣方用药规律。方法:通过人工与计算机检索相结合的方式,收集2001—2021年国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)中发表主题为“化疗性口腔溃疡”“化疗性口腔黏膜炎”“中医药”等相关文献,通过阅读摘要及NoteExpress自动筛选核对建立所需数据库。用频次统计、关联分析和隐含狄利克雷分布(LDA)的统计方法,分析中医临床治疗化疗相关性口腔溃疡的给药方式、用药频次、药物性味归经、常用药对及核心药物组合。结果:纳入临床研究文献93篇,涉及方剂96首,中药141味。给药方式以汤剂口服、药液漱口为主,用药以清热药、补虚药为总纲,具体以甘草、黄连、生地黄为多,药性多为甘、苦、寒,归肺、胃、心、脾经。结论:本研究综合分析了中医临床文献中治疗化疗相关性口腔溃疡的给药方式与用药规律,发现气虚、阴虚火旺是本病的主要病机,治疗上应以补气清热、养阴增液为主要治疗方法。s and NoteExpress automatic screening and checking.Frequency statistics,correlation analysis,and hidden Dirichlet allocation(LDA)statistical methods were adopted to analyze the method of administration,drug frequency,properties,flavors,and meridian tropism of drugs,commonly used drug pairs,and core drug combinations in the clinical TCM treatment of chemotherapy-induced oral ulcer.Results:Ninety-three research articles were included,involving 96 prescriptions and 141 drugs.The main methods of administration were oral decoctions and mouthwash with liquid medicines.The guiding principle of medication was the selection of heat-clearing and deficiency-tonifying drugs,represented by Glycyrrhizae Radix et Rhizoma,Coptidis Rhizoma,and Rehmanniae Radix.The drugs were mainly sweet,bitter,and cold,acting on the lung,stomach,heart,and spleen meridians.Conclusion:This study comprehensively analyzed drug administration methods and medication rules in the treatment of chemotherapy-induced oral ulcer in the clinical literature of TCM and found that qi deficiency,yin deficiency,and hyperactivity of fire are the main pathogenesis of this disease.Therefore,the treatment should be based on invigorating qi,clearing heat,nourishing yin,and increasing fluid.

关 键 词：化疗相关性口腔溃疡 中医药 数据挖掘 隐含狄利克雷分布 用药规律 补气清热 养阴增液 临床文献 

分 类 号：R273[医药卫生—中西医结合] R781.5[医药卫生—中医肿瘤科]