基于中医病因学说探讨HMGB1与IBS-D的相关性  

The Correlation between HMGB1 and IBS-D from the Etiology of TCM

作　　者：谢小玲 黄适[2] 何锦轶 王凯[1] 覃川峰 龚纯 XIE Xiaoling;HUANG Shi;HE Jinyi;WANG Kai;QIN Chuanfeng;GONG Chun(Guangxi University of Chinese Medicine,Nanning 530001,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《西部中医药》2023年第5期112-115,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(81560754);广西中医药大学校级创新项目(YCSY201900110)。

摘　　要：基于中医病因学说探讨高迁移率族蛋白B1(high-mobility group box-1,HMGB1)与腹泻型肠易激综合征(diarrhea predominant-irritable bowel syndrome,IBS-D)的相关性,指出IBS-D中医病因主要涉及外感、饮食、情志、脏腑虚损等方面,病机为五脏功能失调及气机逆乱;HMGB1是参与炎症反应和免疫机制的重要因子,与外感、饮食、情志、脏腑虚损等致病因素有一定联系,因此可从HMGB1角度研究IBS-D,以扩展IBS-D的研究范围。The paper discusses the correlation between HMGB1 and IBS-D based on the etiology of TCM,TCM causes of IBS-D mainly involve external factors,diet,emotion and visceral deficiency,and the pathogenesis belong to the dysfunction of five viscera and Qi movement disturbance;HMGB1 is the important factors involved in inflammatory reaction and immune mechanism,related to pathogenic factors such as external factors,diet,emotion and visceral deficiency to a certain degree,hence,IBS-D could be studied from the angle of HMGB1,so as to expand the scope of IBS-D.

关 键 词：肠易激综合征 腹泻型 高迁移率族蛋白B1 中医病因学说 

分 类 号：R256.34[医药卫生—中医内科学]