白眉蛇毒血凝酶联合奥美拉唑治疗急性上消化道出血临床观察  

Clinical Observation of Hemocoagulase Combined with Omeprazole in the Treatment of Acute Upper Gastrointestinal Bleeding

作　　者：明绘 王华乔 张敏[1] MING Hui;WANG Huaqiao;ZHANG Min(Wuhan Orthopaedics Hospital of Integrated Traditional Chinese and Western Medicine·The Affiliated Hospital of Wuhan Sports University,Wuhan,Hu-bei,China 430079)

机构地区：[1]武汉中西医结合骨科医院·武汉体育学院附属医院,湖北武汉430079

出　　处：《中国药业》2023年第10期99-101,共3页China Pharmaceuticals

基　　金：湖北省自然科学基金[2018CFB116]。

摘　　要：目的探讨白眉蛇毒血凝酶联合奥美拉唑治疗急性上消化道出血的临床疗效。方法选取医院2019年4月至2021年7月收治的急性上消化道出血患者146例,按随机数字表法分为对照组和观察组,各73例。两组患者均予注射用奥美拉唑钠静脉滴注,观察组患者加用注射用白眉蛇毒血凝酶静脉注射。两组均持续治疗7 d。结果观察组总有效率为90.41%,明显高于对照组的72.60%(P<0.05)。治疗后,两组患者超敏C反应蛋白、肿瘤坏死因子-α、穿透素-3水平、Blatchford评分、D-二聚体水平均明显降低,空腹胃液pH明显升高,活化部分凝血活酶时间明显延长(P<0.05);且观察组变化幅度均明显大于对照组(P<0.05)。观察组与对照组不良反应发生率相当(15.07%比9.59%,P<0.05)。结论白眉蛇毒血凝酶联合奥美拉唑治疗急性上消化道出血,可明显减轻患者机体的炎性反应,延长APTT,改善凝血指标、D-D水平及空腹胃液pH。Objective To investigate the clinical efficacy of hemocoagulase combined with omeprazole in the treatment of acute upper gastrointestinal bleeding.Methods A total of 146 patients with acute upper gastrointestinal bleeding admitted to the hospital from April 2019 to July 2021 were selected and divided into the control group and the observation group by the random number table method,with 73 patients in each group.Patients in the two groups were given the intravenous drip of Omeprazole Sodium for Injection,on this basis,patients in the observation group were given Hemocoagulase for Injection intravenously.Both groups were treated continuously for 7 d.Results The total effective rate in the observation group was 90.41%,which was significantly higher than 72.60%in the control group(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),pentraxin-3(PTX-3),D-dimer(D-D)and Blatchford score in the two groups were significantly lower,the pH of fasting gastric juice in the two groups was significantly higher,the activated partial thromboplastin time(APTT)in the two groups was significantly longer(P<0.05),and those in the observation group changed more significantly than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.07%vs.9.59%,P<0.05).Conclusion Hemocoagulase combined with omeprazole in the treatment of acute upper gastrointestinal bleeding can significantly alleviate inflammatory reaction,prolong APTT,improve coagulation indexes,D-D level and pH of fasting gastric juice.

关 键 词：白眉蛇毒血凝酶 奥美拉唑 急性上消化道出血 炎性反应 凝血功能 

分 类 号：R969.4[医药卫生—药理学] R573.2[医药卫生—药学]