卡瑞利珠单抗致免疫相关性多器官损伤一例  

Immune-related multiple organ dysfunction induced by camrelizumab treatment:a case report

作　　者：李梦娇 梁平[1] 单彬[1] 侯娟[1] LI Meng-jiao;LIANG Ping;SHAN Bin;HOU Juan(Department of Pharmacy,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第四医院药学部,石家庄050000

出　　处：《临床药物治疗杂志》2023年第4期85-88,共4页Clinical Medication Journal

摘　　要：本文报道1例由卡瑞利珠单抗引起的免疫检查点抑制剂(ICIs)相关性心肌炎合并肌炎及肝损伤等多器官损伤的案例。患者经卡瑞利珠单抗治疗后出现ICIs相关性多器官损伤,由临床药师参与对其症状与药物关联性进行分析,及时给予激素联合免疫抑制剂治疗,患者症状逐渐缓解,后未再重启免疫治疗。通过此案例,以期为卡瑞利珠单抗引起的ICIs相关性心肌炎合并肌炎及肝损伤不良反应的鉴别和治疗提供思路。The article reports a case of ICIs-related myocarditis accompanied by myositis and liver damage caused by camrelizumab.A patient with esophageal cancer developed immune-related multiple organ dysfunction after administration of camrelizumab,and the symptoms were gradually relieved after treatment of hormone and immunosuppressive agents.The patient did not restart immunotherapy after this adverse reaction.Through this case,we hope to provide methods for the identification,treatment of ICIs-related myocarditis,myositis and liver damage caused by camrelizumab.

关 键 词：卡瑞利珠单抗 免疫检查点抑制剂 心肌炎 肌炎 肝损伤 多器官损伤 药品不良反应 

分 类 号：R979.1[医药卫生—药品]