甲钴胺联合血糖管理对妊娠糖尿病患者血清载脂蛋白CⅢ与脂联素的影响  

Effect of Methylcobalamin Combined with Blood Glucose Management on Serum Apolipoprotein CⅢand Adiponectin in Patients with Gestational Diabetes Mellitus

作　　者：袁媛[1] YUAN Yuan(Department of Obstetrics,Yancheng Maternal and Child Health Care Hospital,Yancheng 224000,China)

机构地区：[1]盐城市妇幼保健院产科,江苏盐城224000

出　　处：《中国药物经济学》2023年第3期63-66,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨甲钴铵联合血糖管理对妊娠糖尿病患者血清载脂蛋白CⅢ、脂联素的影响。方法选取2020年1月至2022年7月盐城市妇幼保健院收治的妊娠糖尿病患者80例作为研究对象,随机分为观察组与对照组,各40例。对照组采取常规血糖管理,观察组在对照组基础上采用甲钴铵治疗。治疗前后测定血清同型半胱氨酸(Hcy)、载脂蛋白CⅢ、脂联素水平,并进行相关性分析。比较两组血糖和体重增幅达标率,记录母婴结局。结果治疗后,观察组载脂蛋白CⅢ、Hcy水平明显低于对照组,脂联素水平明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组Hcy与载脂蛋白CⅢ、脂联素水平之间均无相关性(P>0.05);治疗后,观察组Hcy与载脂蛋白CⅢ、脂联素成中等相关(r=0.641、-0.573,P<0.05);对照组Hcy与载脂蛋白CⅢ弱相关(r=0.473,P<0.05),与脂联素无相关性(r=0.064,P>0.05)。两组治疗1周、2周、3周血糖达标率比较差异无统计学意义(P>0.05);治疗1周两组体重增幅达标率比较差异无统计学意义(P>0.05),治疗2周、3周观察组体重增幅达标率明显高于对照组(P<0.05)。观察组新生儿低血糖发生率明显低于对照组(P<0.05)。结论甲钴铵可有效调节妊娠糖尿病患者的糖脂代谢紊乱,其中的机制可能与降低Hcy水平有关,对改善母婴结局具有潜在价值。Objective To explore the effect of methylcobalamin combined with glucose management on serum apolipoprotein CⅢand adiponectin in patients with gestational diabetes.Methods Eighty patients with gestational diabetes admitted to Yancheng Maternal and Child Health Hospital from January 2020 to July 2022 were selected as the research objects,and were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was treated with routine blood glucose management,and the observation group was treated with methylcobalamin on the basis of the control group.The levels of plasma homocysteine(Hcy),serum apolipoprotein CⅢand adiponectin were measured before and after treatment,and the correlation was analyzed.The standard rate of blood glucose and weight gain per week were compared,and the maternal and infant outcomes were recorded.Results After treatment,the levels of apolipoprotein CⅢand Hcy in the observation group were significantly lower than those in the control group,and the levels of adiponectin were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no correlation between Hcy and apolipoprotein CⅢand adiponectin levels in the two groups(P>0.05).After treatment,Hcy in the observation group was moderately correlated with apolipoprotein CⅢand adiponectin(r=0.641,-0.573,P<0.05).Hcy in the control group was weakly correlated with apolipoprotein CⅢ(r=0.473,P<0.05),but not with adiponectin(r=0.064,P<0.05).There was no statistically significant difference between the two groups in the rate of blood glucose reaching the standard after 1 week,2 weeks and 3 weeks of treatment(P>0.05).There was no statistically significant difference between the two groups in the rate of body weight gain reaching the standard after one week of treatment(P<0.05).The rate of body weight gain reaching the standard in the observation group after two and three weeks of treatment was significantly higher than that

关 键 词：妊娠糖尿病 甲钴胺 血糖管理 载脂蛋白CⅢ 脂联素 同型半胱氨酸 

分 类 号：R714.25[医药卫生—妇产科学] R971[医药卫生—临床医学]