氟马西尼用于静吸复合全麻术后催醒的临床效果观察  

Clinical observation of flumazenil on earlier anesthesia emergence after the inhalation and intravenous general anesthesia

作　　者：邝昆合 郑德志 江进红 李显立 KUANG Kun-he;ZHENG De-zhi;JIANG Jin-hong(Anesthesia Department,Xinxing County People's Hospital,Yunfu 527400,China)

机构地区：[1]新兴县人民医院麻醉科,527400

出　　处：《中国实用医药》2023年第9期116-119,共4页China Practical Medicine

摘　　要：目的探究氟马西尼用于静脉吸入复合全身麻醉(静吸复合全麻)术后催醒的临床效果。方法120例气管内静吸复合全麻经腹腔镜行下腹部手术择期患者为研究对象,按照随机数字表法分为观察组和对照组,每组60例。对照组给予生理盐水静脉注射催醒,观察组给予氟马西尼静脉注射催醒。比较两组呼唤睁眼时间、清醒时间、拔管时间、给药后不同时间段生命体征变化及不良反应发生情况。结果观察组呼唤睁眼时间(5.75±1.15)min、清醒时间(7.11±1.56)min及拔管时间(10.44±2.26)min均明显短于对照组的(9.68±2.26)、(13.26±2.26)、(18.26±3.26)min,差异有统计学意义(P<0.05)。给药后5 min,两组平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO_(2))比较差异无统计学意义(P>0.05);给药后15、30 min,观察组MAP低于对照组,HR、SpO_(2)高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.00%,低于对照组的21.67%,差异有统计学意义(P<0.05)。结论静吸复合全麻术后应用氟马西尼干预可缩短苏醒时间,降低术后不良反应发生率,值得临床应用。Objective To investigate the clinical effect of flumazenil on earlier anesthesia emergence after the inhalation and intravenous general anesthesia.Methods A total of 80 patients undergoing elective lower abdominal surgery via laparoscopy under inhalation and intravenous general anesthesia were studied and divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group received intravenous injection of normal saline,and the observation group received intravenous injection of flumazenil.The eye-opening time,awakening time,extubation time,vital signs change at different time of administration,and occurrence of adverse reactios were compared between the two groups.Results The eye-opening time,awakening time and extubation time were(5.75±1.15),(7.11±1.56)and(10.44±2.26)min in the observation group,which were obviously shorter than those of(9.68±2.26),(13.26±2.26)and(18.26±3.26)min in the control group,and the differences were statistically significant(P<0.05).At 5 min after administration,there was no statistically significant difference between the two groups in the comparison of mean arterial pressure(MAP),heart rate(HR)and oxygen saturation(SpO_(2))(P>0.05).At 15 and 30 min after administration,MAP of the observation group was lower than that of the control group,and HR and SpO_(2)were higher than those of the control group.The differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was lower than that of 21.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion Application of flumazenil after the inhalation and intravenous general anesthesia can reduce the awakening time and lower the incidence of adverse drug reactions,which is worthy of clinical application.

关 键 词：术后催醒 氟马西尼 静脉吸入复合全身麻醉 清醒时间 

分 类 号：R614.2[医药卫生—麻醉学]