白细胞介素-6信号通路在空气污染致不良健康效应中的作用  

Role of interleukin-6 signaling pathway in adverse health effects induced by air pollution

作　　者：邵文溥 彭仁祯 徐燕意 SHAO Wenpu;PENG Renzhen;XU Yanyi(Department of Environmental Health,School of Public Health,Fudan University,Shanghai,200032,China)

机构地区：[1]复旦大学公共卫生学院环境卫生学教研室,上海200032

出　　处：《环境与职业医学》2023年第3期355-361,共7页Journal of Environmental and Occupational Medicine

基　　金：肠道菌群及其代谢产物在大气细颗粒物诱导糖代谢紊乱中的分子机理研究;国家自然科学基金(82003414)。

摘　　要：空气污染是我国乃至全球最重要的环境问题之一,也是影响人类健康的重大公共卫生问题。随着减排等计划的实施,近年来我国空气污染情况有所改善,但仍远高于世界卫生组织的指导水平。大量流行病学与毒理学研究表明短期或长期的空气污染暴露与呼吸系统疾病、心血管系统疾病、代谢性疾病等密切相关,而白细胞介素-6(IL-6)作为一种经典的炎症因子在其中可能发挥着重要的作用。研究发现,IL-6与白细胞介素-6受体(IL-6R)结合后会募集激活糖蛋白130(gp130),进而形成IL-6/IL-6R/gp130复合物,之后在gp130的胞质域中触发非受体酪氨酸激酶/信号转导子和转录激活子、含Src同源2结构域的蛋白酪氨酸磷酸酶-2/促分裂原活化的蛋白激酶、磷脂酰肌醇3-激酶/蛋白激酶B三种信号通路进而参与到多种生理病理过程中。通过对IL-6信号通路以及近年来关于其在空气污染致不良健康效应中的作用机制研究进行系统梳理,有望为未来相关防治政策的提出提供依据。Air pollution is one of the most important environmental issues in China and worldwide,as well as a critical public health problem affecting human health.With the implementation of emission reduction and other programs,the air quality in China has been improved dramatically in recent years,but is still worse than the WHO guideline recommended levels.Numerous epidemiological and toxicological studies have shown that short-term or long-term exposure to air pollution is strongly associated with respiratory diseases,cardiovascular diseases,diabetes,and so forth,in which interleukin-6(IL-6),a well-known inflammatory factor,may play an important role.Studies have found that IL-6 can bind to interleukin-6 receptor(IL-6R),which leads to the recruiting and activation of glycoprotein 130,and then the formed IL-6/IL-6R/gp130 complex triggers the janus kinase/signal transducer and activator of transcription,Src homology-2 domain-containing protein tyrosine phosphatase-2/mitogen-activated protein kinase,and phosphatidylinositol 3-kinase/protein kinase B signaling pathways.All of these signaling pathways are found to be involved in a variety of physiopathological processes.In the present review,information about the IL-6 signaling pathway and its role in air pollution-induced adverse health effects was systematically reviewed,hoping to provide insights for the future prevention and control policies.

关 键 词：空气污染 白细胞介素-6 信号通路 呼吸系统 毒理学效应 分子机制 

分 类 号：R122.7[医药卫生—环境卫生学]