清热类复方改善2型糖尿病的作用机制研究进展  

Mechanism of heat-clearing prescriptions in alleviating type 2 diabetes mellitus:a review

作　　者：王艳[1] 梁建庆[1] 朱向东 高鹏鹏 岑曦 梁永林[1] 李洁[1] 王盈蕴 司晓丽[1] WANG Yan;LIANG Jian-qing;ZHU Xiang-dong;GAO Peng-peng;CEN Xi;LIANG Yong-lin;LI Jie;WANG Ying-yun;SI Xiao-li(Gansu University of Chinese Medicine,Lanzhou 730000,China;Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]宁夏医科大学,宁夏银川750004

出　　处：《中国中药杂志》2023年第7期1711-1723,共13页China Journal of Chinese Materia Medica

基　　金：甘肃省自然科学基金一般项目(21JR7RA599);甘肃省产业支撑计划项目(2021CYZC-03);兰州市科学技术局人才创新创业项目(2019-RC-100)。

摘　　要：2型糖尿病(type 2 diabetes mellitus, T2DM)是常见的慢性代谢性疾病,临床常伴随明显的内热证候。针对内热临床广泛应用清热类复方从清郁热、实热、湿热、痰热、热毒等方面治疗T2DM的不同热证,疗效显著。降糖药物的作用机制一直是国内外科研人员的研究热点,近年来各清热类复方从不同角度开展的基础研究逐年增加。为进一步阐明清热类复方降糖机制,发现特异性作用机制,该文对近十年国内外治疗T2DM的常用清热类复方的基础研究进行了系统综述,以期为相关研究提供参考。Type 2 diabetes mellitus(T2DM),a common chronic metabolic disease,is often accompanied by internal heat syndrome.Heat-clearing prescriptions are widely used to treat different heat syndromes of T2DM from the aspects of cl earing stagnant heat,excess heat,damp heat,phlegm heat,and heat toxin,demonstrating remarkable effects.The mechanism of blood sugar-lowering agents has always been a hotspot of research.Recently,the basic studies of heat-clearing prescriptions from different perspectives have been increasing year by year.To clarify the mechanisms of heat-clearing prescriptions and find specific mechanisms,we systematically reviewed the basic studies of heat-clearing prescriptions commonly used for the treatment of T2DM in the past decade,intending to provide a reference for related research.

关 键 词：清热类复方 2型糖尿病 大柴胡汤 白虎汤 大黄黄连泻心汤 葛根芩连汤 小陷胸汤 黄连解毒汤 

分 类 号：R259[医药卫生—中西医结合]