作用于钾离子通道的抗心律失常中药活性成分研究进展  

Antiarrhythmic active components in traditional Chinese medicine acting on potassium channels

作　　者：王慈 曹雅雯 张璇 杨志华 张泽宇 李明伟 王贤良[1,2] 毛静远 WANG Ci;CAO Ya-wen;ZHANG Xuan;YANG Zhi-hua;ZHANG Ze-yu;LI Ming-wei;WANG Xian-liang;MAO Jing-yuan(Department of Cardiology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院心血管科,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津中医药大学研究生院,天津301617

出　　处：《中国中药杂志》2023年第7期1792-1799,共8页China Journal of Chinese Materia Medica

基　　金：教育部创新团队发展计划项目(IRT-16R54);中医药传承与创新“百千万”人才工程岐黄学者项目;国家中医药行业科研专项(201407001-6A)。

摘　　要：心律失常是心脏电生理活动紊乱的外在征象,可见于健康人群和各种心脏病患者,常与其他心血管疾病互为因果。心肌的收缩与舒张离不开离子的运动,心肌细胞膜及其细胞器膜存在多种离子通道,心肌各离子间动态平衡是维持心肌电稳态的重要因素。钾离子通道种类复杂、分布广泛,其全程参与心肌细胞静息电位和动作电位,在维持心脏正常电生理活动中发挥重要作用,钾离子通道失调是心律失常的发病机制之一。中药在治疗心律失常方面具有独特优势,大量中药制剂在心律失常相关疾病的临床治疗中疗效确切,其活性成分复杂、作用靶点多样,抗心律失常效应机制或与对钾离子通道的影响有关。该文主要对作用于不同钾离子通道的中药活性成分研究进行综述,以期为临床用药与开发提供参考。Arrhythmia is an external manifestation of cardiac electrophysiological disorder.It exists in healthy people and patients with various heart diseases,which is often associated with other cardiovascular diseases.The contraction and diast ole of myocardium are inseparable from the movement of ions.There are many ion channels in the membrane and organelle membrane of myocardium.The dynamic balance of myocardial ions is vital in maintaining myocardial electrical homeostasis.Potassium ion channels that have a complex variety and a wide distribution are involved in the whole process of resting potential and action potential of cardiomyocytes.Potassium ion channels play a vital role in maintaining normal electrophysiological activity of myocardium and is one of the pathogenesis of arrhythmia.Traditional Chinese medicine(TCM)has unique advantages in treating arrhythmia for its complex active components and diverse targets.A large number of TCM preparations have definite effect on treating arrhythmia-related diseases,whose antiarrhythmic mechanism may be related to the effect on potassium channel.This article mainly reviewed the relevant studies on the active components in TCM acting on different potassium channels to provide references for clinical drug use and development.

关 键 词：钾离子通道 心律失常 中药活性成分 研究进展 

分 类 号：R285[医药卫生—中药学]