模式生物果蝇在中药及天然化合物防治精神神经疾病的研究与应用进展  

Research and application of model fruit fly in prevention and treatment of neuropsychiatric disorders by traditional Chinese medicine and natural compounds:a review

作　　者：王瑞英 艾志福[1,2] 李惠珍 薛冰 刘亚丽 杨明 朱根华[1,2] 苏丹[1,2] 宋永贵[1,2] WANG Rui-ying;AI Zhi-fu;LI Hui-zhen;XUE Bing;LIU Ya-li;YANG Ming;ZHU Gen-hua;SU Dan;SONG Yong-gui(Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Brain Diseases with Cognitive Impairment,Jiangxi Province,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Key Research Room for Depression Syndrome Animal Models and Chinese Medicine Efficacy Evaluation(Prevention and Treatment of Mental Disorders Brain Disease)of Jiangxi Traditional Chinese Medicine Administration,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Key Eficacy and Safety Evaluation Laboratory of Jiangxi Health Commission,Nanchang Medical College,Nanchang 330004,China;Jiangxi Guxiang Jinyun Comprehensive Health Industry Co.,Ltd.,Nanchang 330029,China)

机构地区：[1]江西中医药大学,中医药防治认知障碍脑疾病江西省重点实验室,江西南昌330004 [2]江西中医药大学,抑郁症中医证候动物模型、中药药效(防治精神障碍脑疾病)评价江西省中医药管理局重点研究室,江西南昌330004 [3]南昌医学院药效与安全性评价江西省卫生健康委员会重点实验室,江西南昌330004 [4]江西古香今韵大健康产业有限公司,江西南昌330029

出　　处：《中国中药杂志》2023年第6期1438-1445,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82060808);江西省教育厅科技计划项目(GJJ201206,GJJ218915);江西省中医药科技计划重点项目(2021Z011,2020Z003)。

摘　　要：果蝇作为一种重要的模式生物,不仅具有突出的遗传学特征,相对完善的神经系统,而且还具有繁殖快、成本低等优势,成为了近年来研究精神神经疾病的重要工具,在生命科学领域彰显出巨大的潜力。精神神经疾病发病率逐渐增长,并具有致残率高、病死率低等特点。从全球医药市场规模看,该类疾病的用药需求仅次于心脑血管疾病,已成为全球第二大用药领域,目前其临床需求仍远未满足,亟待推进此类疾病的药物研发。由于此类药物的研发失败率高,研发周期较长,因此通过合理选用模式生物,能够实现该类药物的快速筛选,缩短新药开发周期,从而降低精神神经疾病的新药开发成本并提高其成功率。该文对果蝇在目前较为常见的几种精神神经疾病的应用及研究进展进行了综述,以期为模式生物果蝇在中药研究和应用提供新思路。As an important model animal,fruit fly is characterized by outstanding genetic characteristics,relatively perfect nervous system,rapid reproduction,and low cost.Thus,it has been applied in the research on neuropsychiatric disorders in recent years,showing great potential in life science.The incidence of neuropsychiatric disorders has been on the rise,and the disorders have high disability rate and low case fatality rate.The global drug demand for such diseases is second only to cardiovascular and cerebrovascular diseases.At the moment,the demand of the drugs for the diseases have been rising,and it is an urgent task to develop related drugs.However,the research and development of the drugs are time-intensive and have a high failure rate.A suitable animal model can help shorten the time for drug screening and development,thereby reducing the cost and failure rate.This study reviews the application of fruit flies in several common neuropsychiatric disorders,which is expected to provide new ideas for the research and application of the model animals in traditional Chinese medicine.

关 键 词：果蝇 模式生物 中药 天然化合物 精神神经疾病 

分 类 号：R285.5[医药卫生—中药学]