川木香属植物的化学成分及药理作用研究进展  

Chemical constituents in Dolomiaea plants and their pharmacological activities:a review

作　　者：吕燕慧 陈威 魏艳平 隗鑫曈 王杰 丁倩倩 李展鸿 贺吉香[2] 祖先鹏 LYU Yan-hui;CHEN Wei;WEI Yan-ping;WEI Xin-tong;WANG Jie;DING Qian-qian;LI Zhan-hong;HE Ji-xiang;ZU Xian-peng(School of Pharmacy,Naval Medical University,Shanghai 200433,China;School of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China;School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510640,China)

机构地区：[1]海军军医大学药学院,上海200433 [2]山东中医药大学药学院,山东济南250355 [3]安徽中医药大学药学院,安徽合肥230012 [4]广东药科大学药学院,广东广州510640

出　　处：《中国中药杂志》2023年第6期1463-1482,共20页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82004215,82003624,82141203);国家重点研发计划项目(2019YFC1711006);上海市卫生健康委员会卫生行业临床研究专项(20204Y0326);上海市中医药传承创新发展三年行动计划项目(ZY(2021-2023)-0401);上海市扬帆计划(20YF1458700,20YF1459000);海军军医大学大学生创新能力培养计划(ZD2021022,MS2021062);海军军医大学“深蓝”工程启航计划。

摘　　要：川木香属Dolomiaea植物为菊科多年生草本植物,药用历史悠久。该属植物化学成分种类繁多,主要包括倍半萜类、苯丙素类、三萜类和甾体类成分。川木香属植物提取物和化学成分具有多种药理作用,如抗炎、抗菌、抗肿瘤、抗胃溃疡以及保肝利胆等。但目前对川木香属植物综述性报道较少,该文对川木香属植物的化学成分和药理作用的最新研究进展进行系统综述,以期为该属植物的进一步开发和研究提供参考依据。Dolomiaea plants are perennial herbs in the Asteraceae family with a long medicinal history.They are rich in chemical constituents,mainly including sesquiterpenes,phenylpropanoids,triterpenes,and steroids.The extracts and chemical constituents of Dolomiaea plants have various pharmacological effects,such as anti-inflammatory,antibacterial,antitumor,anti-gastric ulcer,hepatoprotective and choleretic effects.However,there are few reports on Dolomiaea plants.This study systematically reviewed the research progress on the chemical constituents and pharmacological effects of Dolomiaea plants to provide references for the further development and research of Dolomiaea plants.

关 键 词：川木香属 倍半萜类 抗炎 抗菌 抗肿瘤 抗胃溃疡 保肝利胆 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]