氯氰菊酯的神经毒性及其机制的研究进展  

Research progress on neurotoxicity and mechanism of cypermethrin

作　　者：刘英华[1] 张书婧[1] 张静[1] 周殿明[1] 钱智勇[1] LIU Ying-hua;ZHANG Shu-jing;ZHANG Jing;ZHOU Dian-ming;QIAN Zhi-yong(Health Inspection and Testing Institute,Tianjin Centers for Disease Control and Prevention,Tianjin,300011,China)

机构地区：[1]天津市疾病预防控制中心卫生检验检测所,天津300011

出　　处：《职业与健康》2023年第6期855-860,共6页Occupation and Health

摘　　要：氯氰菊酯是一种拟除虫菊酯类杀虫剂,在农业及卫生害虫防治中被广泛应用,其对人类产生的潜在毒性也日益受到人们的关注。氯氰菊酯的主要的靶器官是神经系统,其可通过对神经递质、离子通道、脂质过氧化作用等产生影响而发挥其神经毒性作用。本文对氯氰菊酯对哺乳动物的神经毒性及其机制的研究进展进行综述,以期为氯氰菊酯的安全生产和使用提供参考。The cypermethrin(CYP)is a synthetic pyrethroid insecticide.Because CYP is widely used in agricultural and sanitary pests control,its potential toxicity to humans has atracted increasing attention.The research shows that the nervous system is its main target organ,and cypermethrin can exert its neurotoxic effect by affecting neurotransmitters,ion channels,lipid peroxidation and so on.This paper summarizes the research progress on neurotoxicity of cypermethrin to mammals and its mechanism,so as to provide reference for the safe production and use of cypermethrin.

关 键 词：氯氰菊酯 神经毒性 毒性机制 

分 类 号：R114[医药卫生—卫生毒理学]