妊娠期高血压疾病和妊娠期糖尿病对母胎体系中铜和铬分布的影响  

Effects of gestational hypertension and gestational diabetes mellitus on the distribution of copper and chromium in the maternal-fetal system

作　　者：丁爱玲 李飞 董旭东[2] 李旻[3] DING Ai-ling;LI Fei;DONG Xu-dong;LI Min(Medical College of Kunming University of Science and Technology,Yunnan,Kunming 650500,China;Department of Obstetrical,the First People's Hospital of Yunnan Province,the Affiliated Hospital of Kunming University of Science and Technology,Yunnan,Kunming,650500,China;不详)

机构地区：[1]昆明理工大学医学院,云南昆明650500 [2]云南省第一人民医院产科昆明理工大学附属医院产科,云南昆明650500 [3]北京医院妇产科、国家老年医学中心、中国医学科学院老年医学研究院

出　　处：《中国妇幼保健》2023年第9期1553-1556,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目(42167060);云南省卫生健康委员会高级人才项目(L-2018006);云南省院士专家工作站项目(202005AF150033);云南省科技厅昆明医科大学应用基础研究联合专项项目(202001AY070001-128)。

摘　　要：目的探讨云南省昆明市妊娠期高血压疾病(HDCP)和妊娠期糖尿病(GDM)母胎体系中铜(Cu)和铬(Cr)的分布及转运特征。方法选取2015年1月—2019年12月在云南省第一人民医院产科住院分娩的产妇72例为研究对象,采用电感耦合等离子质谱法(ICP-MS)测定其配对样本(母血、胎盘及脐血)中Cu和Cr的含量,采用SPSS软件进行数据分析。结果正常组母胎体系中Cu分布特征胎盘[(43.96±11.13)ng/kg]>母血[(31.22±9.10)ng/kg]>脐血[(8.28±4.21)ng/kg],差异均具有统计学意义(t=-4.772、12.318及16.145,均P<0.05),而GDM组与HDCP合并GDM组Cu分布不同:母血>胎盘>脐血。GDM组胎盘Cu[(31.96±12.54)μg/kg]显著低于正常组胎盘[(43.96±11.13)μg/kg],差异具有统计学意义(t=3.181,P<0.05),HDCP组脐血Cu[(21.58±24.42)μg/kg]显著高于正常组脐血[(8.28±4.21)μg/kg],差异具有统计学意义(t=-2.882,P<0.05)。正常组与各个疾病组Cr分布特征相同:脐血>母血>胎盘。GDM组[(0.32±0.24)μg/kg]与HDCP合并GDM组[(0.30±0.18)μg/kg]胎盘Cr含量显著低于正常组胎盘[(0.50±0.27)μg/kg],差异均有统计学意义(t=2.197、2.665,均P<0.05),HDCP组[(3.49±1.37)μg/kg]与HDCP合并GDM组[(2.79±0.49)μg/kg]脐血Cr含量显著高于正常组脐血[(1.15±1.68)μg/kg],差异均有统计学意义(t=-4.524、-2.843,均P<0.05)。结论GDM和HDCP合并GDM的发生改变了Cu在母胎体系中的分布特征,HDCP和GDM影响了Cu和Cr的胎盘代谢和转运,从而可能增加胎儿的健康风险。Objective To investigate the distribution and transport characteristics of copper(Cu)and chromium(Cr)in maternal fetal system of gestational hypertension(HDCP)and gestational diabetes(GDM)in Kunming,Yunnan province.Methods A total of 72 women who gave birth in the Obstetrics Department of the First People's Hospital of Yunnan Province from January 2015 to December 2019 were selected as the research objects.The contents of Cu and Cr in paired samples(maternal blood,placenta and umbilical cord blood)were determined by inductively coupled plasma mass spectrometry.SPSS software was used for data analysis.Results The distribution characteristics of Cu in normal maternal fetal system were placenta[(43.96±11.13)μg/kg]>maternal blood[(31.22±9.1)μg/kg]>umbilical cord blood[(8.28±4.21)μg/kg],the difference was statistically significant(t=-4.772,12.318,16.145,all P<0.05),but the distribution of Cu in GDM group and HDCP combined with GDM group was different:maternal blood>placenta>umbilical cord blood.The placental Cu in the GDM group[(31.96±12.54)μg/kg]was significantly lower than that in the normal group[(43.96±11.13)μg/kg],the difference was statistically significant(t=3.181,P<0.05).The umbilicalcord blood Cu in the HDCP group[(21.58±24.42)μg/kg]was significantly higher than that in the normal group[(8.28±4.21)μg/kg],the difference was statistically significant(t=-2.882,P<0.05).The distribution characteristics of Cr in normal group and all disease groups were the same:umbilical cord blood>maternal blood>placenta.The content of Cr in placenta of GDM group[(0.32±0.24)μg/kg]and HDCP combined with GDM group[(0.30±0.18)μg/kg]was significantly lower than that of normal group[(0.50±0.27)μg/kg],with statistical significance(t=2.197,2.665,all P<0.05).The content of Cr in umbilical cord blood of HDCP group[(3.49±1.37)μg/kg]and HDCP combined with GDM group[(2.79±0.49)μg/kg]was significantly higher than that of normal group[(1.15±1.68)μg/kg],and the differences were statistically significant(t=-4.524,-2.843,

关 键 词：妊娠期高血压疾病 妊娠期糖尿病 母胎体系 铜 铬 胎盘转运 

分 类 号：R714.2[医药卫生—妇产科学]