乙酰半胱氨酸联合多烯磷脂酰胆碱对甲状腺功能亢进性肝损伤患者氧化应激产物、血清转化生长因子-β1及游离脂肪酸水平的影响  

Effects of acetylcysteine combined with polyene phosphatidylcholine on levels of oxidative stress products,serum transforming growth factor-β1 and free fatty acids in patients with hyperthyroid liver injury

作　　者：冯克娜 曹磊[1] 张淼[1] 李丽莉 FENG Kena;CAO Lei;ZHANG Miao;LI Lili(Department of Endocrinology,the NO.2 Hospital of Baoding,Baoding 071051,Hebei Province,China)

机构地区：[1]保定市第二医院内分泌科,河北保定071051

出　　处：《世界临床药物》2023年第3期252-257,274,共7页World Clinical Drug

摘　　要：目的探讨乙酰半胱氨酸联合多烯磷脂酰胆碱对甲状腺功能亢进性肝损伤患者氧化应激(oxidative stress,OS)产物、血清转化生长因子(transforming growth factor,TGF)-β1、游离脂肪酸(free fatty acid,FFA)水平的影响。方法回顾性分析保定市第二医院内分泌科2020年1月至2021年3月接诊的94例甲状腺功能亢进性肝损伤患者临床资料,按随机数表法分为观察组及对照组,每组47例。在常规治疗基础上,对照组采用多烯磷脂酰胆碱胶囊治疗,观察组在对照组基础上,联合乙酰半胱氨酸注射液治疗,均持续治疗4周。比较两组临床疗效、谷氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin,TBil)、γ-谷氨酰转肽酶(γ-glutamyl transpeptidase,γ-GT)、OS产物[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)]、血清TGF-β1、FFA水平变化及不良反应。结果观察组临床疗效总有效率高于对照组(89.36%vs 61.70%),差异有统计学意义(P<0.05)。观察组ALT、AST、TBiL及γ-GT水平较对照组均低,差异有统计学意义(P<0.05)。观察组SOD、GSH-Px水平较对照组高,MDA水平较对照组低,差异有统计学意义(P<0.05)。观察组血清TGF-β1、FFA水平较对照组均低,差异有统计学意义(P<0.05)。结论乙酰半胱氨酸联合多烯磷脂酰胆碱治疗甲状腺功能亢进性肝损伤患者效果显著,有助于积极调节OS产物、血清TGF-β1、FFA水平,促进肝功能恢复,值得临床推广。Objective To explore the effects of acetylcysteine combined with polyene phosphatidylcholine on the levels of oxidative stress(OS)products,serum transforming growth factor(TGF)-β1 and free fatty acids(FFA)in patients with hyperthyroid liver injury.Methods Clinical data of 94 patients with hyperthyroidism liver injury admitted to department of endocrinology,the NO.2 hospital of Baoding from January 2020 to March 2021 were retrospectively analyzed,and were divided into observation group and control group according to random number table method,with 47 cases in each group.On the basis of conventional treatment,the control group was treated with polyene phosphatidylcholine capsules,and the observation group was treated with acetyl cysteine injection on the basis of the control group,and the treatment lasted for 4 weeks.Alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBiL),γ-glutamyl transpeptidase(γ-GT),OS product[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSHPx)],serum TGF-β1,FFA level changes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(89.36%vs 61.70%),the difference was statistically significant(P<0.05).The levels of ALT,AST,TBiL andγ-GT in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The SOD and GSH-Px levels in the observation group were higher than those in the control group,while the MDA level was lower,and the differences were statistically significant(P<0.05).Serum TGF-β1 and FFA levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Acetylcysteine combined with polyene phosphatidylcholine had significant efficacy in the treatment of patients with hyperthyroidism liver injury,which could help to positively regulate the levels of OS products,serum TGF-β1 and FFA,and p

关 键 词：乙酰半胱氨酸 多烯磷脂酰胆碱 甲状腺功能亢进症 氧化应激 转化生长因子-β1 游离脂肪酸 肝功能 

分 类 号：R581.1[医药卫生—内分泌] R575[医药卫生—内科学]