FGF23、orexin A、BMP-7在肾衰竭患者中的表达水平及与临床预后的关系  

Expression levels of FGF23,orexin A and BMP-7 in patients with renal failure and their relationship with clinical prognosis

作　　者：韩丽丽[1] 张平 王芳[1] 陈珊珊[1] 扈瑞春[1] 张绍菊[2] HAN Li-li;ZHANG Ping;WANG Fang;CHEN Shan-shan;HU Rui-chun;ZHANG Shao-ju(Department of Nephrology,Langfang People′s Hospital,Hebei Province,Langfang 065000,China;Department of Laboratory Medicine,Langfang People′s Hospital,Hebei Province,Langfang 065000,China)

机构地区：[1]河北省廊坊市人民医院肾内科,河北廊坊065000 [2]河北省廊坊市人民医院检验科,河北廊坊065000

出　　处：《河北医科大学学报》2023年第5期512-516,546,共6页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20221595)。

摘　　要：目的探讨成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)、食欲素A(orexin A)、骨形态发生蛋白7(bone morphogenetic protein-7,BMP-7)在肾衰竭患者中的表达水平及与临床预后的关系。方法选取收治的肾衰竭患者65例为研究组,另选同期健康体检人群65例为对照组。研究对象均检测血液中FGF23、orexin A、BMP-7水平并进行比较分析;进行1年随访后,比较不同临床预后患者的临床资料,并分析FGF23、orexin A、BMP-7与肾衰竭患者临床不良预后的相关性;COX回归分析影响肾衰竭患者预后因素,分析FGF23、orexin A、BMP-7预测肾衰竭患者预后不良的接受者操作特性曲线(receiver operating characteristic curve,ROC)图。结果与对照组比较,研究组FGF23、orexin A表达水平及血肌酐、尿酸、血尿素氮、C反应蛋白(C-reactive protein,CRP)水平较高,BMP-7表达水平较低(P<0.05);预后良好组48例,预后不良组17例,与预后良好组比较,预后不良组血肌酐、尿酸、血尿素氮、CRP、FGF23、orexin A表达水平较高,BMP-7表达水平较低(P<0.05);FGF23、orexin A与肾衰竭患者临床不良预后呈正相关,BMP-7与肾衰竭患者临床不良预后呈负相关(P<0.05);FGF23、orexin A是肾衰竭患者预后不良的独立危险因素,BMP-7是保护因素(P<0.05);FGF23、orexin A、BMP-7 AUC分别为0.920、0.697、0.849。结论肾衰竭患者FGF23、orexin A表达水平较高,BMP-7表达水平较低,对肾衰竭患者的预后具有预测价值。Objective To investigate the expression levels of fibroblast growth factor 23(FGF23),orexin A and bone morphogenetic protein-7(BMP-7)in patients with renal failure and their relationship with clinical prognosis.Methods A total of 65 patients with renal failure were selected as the research group,and 65 healthy people who underwent physical examination during the same period were selected as the control group.The levels of FGF23,orexin A and BMP-7 in the blood of all subjects were detected,compared and analyzed.After 1-year follow-up,the clinical data of patients with different clinical prognoses were compared,and the correlation between FGF23,orexin A,BMP-7 and poor clinical prognosis of renal failure patients was analyzed.COX regression analysis was used to analyze prognostic factors in patients with renal failure,and the receiver operating characteristic curve(ROC)curve of FGF23,orexin A and BMP-7 in predicting poor prognosis in patients with renal failure was analyzed.Results Compared with the control group,FGF23 and orexin A expression levels,blood creatinine(CREA),uric acid(UA),blood urea nitrogen(BUN)levels and C-reactive protein(CRP)were higher,while BMP-7 expression levels were lower in the research group(P<0.05).There were 48 cases in the good prognosis group and 17 cases in the poor prognosis group.Compared with the good prognosis group,patients in the poor prognosis group had higher expression levels of CREA,UA,BUN,CRP,FGF23 and orexin A and lower expression levels of BMP-7(P<0.05).FGF23 and orexin A were positively correlated with poor clinical prognosis in patients with renal failure,while BMP-7 was negatively correlated with poor clinical prognosis in patients with renal failure(P<0.05).FGF23 and orexin A were independent risk factors for poor prognosis in patients with renal failure,and BMP-7 was a protective factor(P<0.05).The AUC of FGF23,orexin A,and BMP-7 was 0.920,0.697,and 0.849,respectively.Conclusion The expression levels of FGF23 and orexin A in patients with renal failure are higher,and t

关 键 词：肾功能不全 成纤维细胞生长因子23 食欲素A 

分 类 号：R692.5[医药卫生—泌尿科学]