口服特比萘芬与伊曲康唑治疗儿童头癣的疗效比较  

Comparison of oral terbinafine versus itraconazole in the treatment of tinea capitis in children

作　　者：周亚彬 肖媛媛[1] 晁金京 马琳[1] Zhou Yabin;Xiao Yuanyuan;Chao Jinjing;Ma Lin(Department of Dermatology,Beijing Children′s Hospital,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心、首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《中华皮肤科杂志》2023年第5期438-440,共3页Chinese Journal of Dermatology

基　　金：国家重点研发计划项目(2022YFC2504800);首都卫生发展科研专项项目(首发2020-2-4078)。

摘　　要：目的比较口服特比萘芬与伊曲康唑治疗儿童头癣的疗效。方法2021年1-12月北京儿童医院皮肤科门诊头癣患儿53例,采用随机数字表法分为特比萘芬治疗组(体重<20 kg,剂量62.5 mg/d;体重20~40 kg,剂量125 mg/d;体重>40 kg,剂量250 mg/d)和伊曲康唑治疗组(3~5 mg·kg^(-1)·d^(-1))。使用SPSS23.0软件进行统计分析,组间计数资料比较采用χ^(2)检验或Fisher确切概率法。结果特比萘芬治疗组27例(白癣17例、脓癣10例),治愈14例(51.85%),其中白癣5例,脓癣9例。伊曲康唑治疗组26例(白癣17例、脓癣9例),治愈25例(96.15%),其中白癣16例,脓癣9例。伊曲康唑组的疗效显著高于特比萘芬组,χ^(2)=13.37,P<0.001。结论伊曲康唑治疗儿童白癣的效果优于特比萘芬,但两药治疗儿童脓癣的疗效相当。Objective To compare the efficacy and safety of oral terbinafine versus itraconazole in the treatment of pediatric tinea capitis.Methods From January 2021 to December 2021,a randomized clinical trial was conducted among 53 children with tinea capitis in Beijing Children′s Hospital.These patients were randomly divided into 2 groups by using a random number table:terbinafine group treated with oral terbinafine at different doses(weight<20 kg,dose:62.5 mg/d;weight 20-40 kg,dose:125 mg/d;weight>40 kg,dose:250 mg/d),while itraconazole group treated with oral itraconazole at doses of 3-5 mg·kg^(-1)·d^(-1).Statistical analysis was performed using SPSS 23.0 software,and enumeration data were compared between groups by using chi-square test or Fisher′s exact test.Results Totally,27 patients were treated with oral terbinafine,including 17 with tinea alba and 10 with kerion;26 were treated with oral itraconazole,including 17 with tinea alba and 9 with kerion.After treatment,14(51.85%)patients were cured in the terbinafine group,including 5 with tinea alba and 9 with kerion,while 25(96.15%)were cured in the itraconazole group,including 16 with tinea alba and 9 with kerion.The response rate was significantly higher in the itraconazole group than in the terbinafine group(χ^(2)=13.37,P<0.001).Conclusion The efficacy of itraconazole was superior to that of terbinafine in the treatment of pediatric tinea alba,but their efficacy was equivalent in the treatment of pediatric kerion.

关 键 词：头癣 特比萘芬 伊曲康唑 儿童 

分 类 号：R756.1[医药卫生—皮肤病学与性病学]