血清补体C1q水平与2型糖尿病视网膜病变的相关性研究  

Correlation between Serum Complement C1q Level and Type 2 Diabetes Retinopathy

作　　者：艾合麦提江·凯赛尔 路璐 阿孜古丽·阿不都热合曼 陈海云 李霞 许爱敏 Aihemaitijiang Kaisaier;LU Lu;Aziguli Abudureheman;CHEN Hai-yun;LI Xia;XU Ai-min(Department of Clinical Laboratory,The First People’s Hospital of Kashgar,Kashgar 844099,China)

机构地区：[1]喀什市第一人民医院,喀什市844099

出　　处：《微循环学杂志》2023年第2期38-42,共5页Chinese Journal of Microcirculation

基　　金：新疆维吾尔自治区卫生计生委青年医学科技人才专项(WJWY-201843);新疆维吾尔自治区科学技术厅-天山创造团队(2021D14003);喀什地区第一人民医院“珠江学者天山英才”合作专家工作室创新团队计划(KDYY202019)。

摘　　要：目的:探讨血清补体C1q水平与2型糖尿病视网膜病变(DR)的相关性。方法:纳入2021-09—2022-09喀什地区第一人民医院内分泌科住院的2型糖尿病患者146例,根据有无并发DR分为DR组67例和糖尿病组(DM组)79例。纳入同期体检正常者81例作为正常对照(对照组)。全自动生化分析仪检测C1q、C反应蛋白(CRP)、血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平;采用糖化血红蛋白仪检测糖化血红蛋白(HbA1c)水平。Logistic回归分析C1q与DR的相关性,ROC曲线分析C1q对DR的诊断效能。结果:与对照组比较,DM组和DR组患者FPG、HbA1c、TC、TG(DM组除外)、LDL-C(DM组除外)、CRP和C1q水平均升高;与DM组比较,DR组血清C1q水平明显升高,差异均有统计学意义(P<0.05或P<0.01)。在充分调整了协变量后,Logistic回归分析显示,三种模型中,C1q水平均与DR的发生呈正相关。ROC曲线显示,C1q诊断DR的ROC曲线下面积为0.716(0.631-0.801),截断值为170.45mg/L,敏感度为0.851,特异度为0.544。结论:C1q是T2DM和DR患病的危险因素,监测C1q水平变化对评估T2DM的病程进展及DR的发生具有参考价值。Objective:To investigate the correlation between serum complement Clq level and type 2 diabetes retinopathy(DR).Method:146 patients with type 2 diabetes from September 2021 to September 2022 were divided into DR group(67 cases)and diabetes group(79 cases)according to whether DR was complicated or not.81 normal individuals who underwent physical examination during the same period were included as normal controls(control group).The levels of Clq,C-reactive protein(CRP),blood glucose(FPG),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were detected by automatic biochemical analyzer.The level of glycated hemoglobin(HbA1c)was detected by glycated hemoglobin analyzer.ROC curve was used to analyze the diagnostic efficacy of Clq in type 2 diabetes,and logistic regression was used to analyze the correlation between Clq and DR.Results:Compared with the control group,the levels of FPG,HbA1c,TC,TG(except for the DM group),LDL-C(except for the DM group),CRP,and Clq in both the DM and DR groups were increased.Compared with the DM group,the serum Clq level in the DR group was increased significantly(P<0.05).After fully adjusting for covariates,logistic regressio analysis showed that Clq levels were positively correlated with the occurrence of DR in all three models.The ROC curve shows that the area under the ROC curve for Clq diagnosis of DR is 0.716(0.631-0.801),with a cutoff value of 170.45 mg/L,the sensitivity was 0.851,and the specificity was 0.544.Conclusion:Clq is a risk factor for T2DM and DR,and monitoring changes of Clq levels has reference value for evaluating the progression of T2DM and the occurrence of DR.

关 键 词：补体C1Q 糖尿病视网膜病变 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌]