人羊膜来源干细胞的生物学特性及应用潜力  

Biological Characteristics and Application Potential of Human Amnion-derived Stem Cells

作　　者：靖金鹏 朱朝军[2,3] 张朝晖 JING Jin-peng;ZHU Chao-jun;ZHANG Zhao-hui(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Institute of TCM Ulcers,Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学研究生院,天津300193 [2]天津中医药大学第二附属医院,天津300250 [3]天津中医药大学中医疮疡研究所,天津300250

出　　处：《中国生物工程杂志》2023年第4期79-91,共13页China Biotechnology

基　　金：天津市教委科研计划重点项目(2021ZD020)。

摘　　要：干细胞移植是一种有潜力的替代治疗方案,虽然大量实验模型研究已经证实了干细胞移植能够修复受损或退化的组织并恢复其功能,但是在实际治疗中仍面临诸多困难,如免疫排斥、伦理障碍以及致瘤性等。围产期干细胞可以解决干细胞治疗所面临的问题,被认为是潜在的可靠干细胞来源。与其他干细胞相比,人羊膜来源干细胞(human amniotic stem cells,hAMSCs)具有显著优势。动物实验发现,hAMSCs具有高分化潜能以及免疫调节活性,在妇科疾病、神经系统疾病、肾脏疾病、肺部疾病、皮肤疾病、糖尿病、癌症等多种疾病的治疗中表现出了巨大潜力。随着科学的进步以及临床的迫切需求,hAMSCs的临床应用也逐渐突破了传统治疗的局限性。综述hAMSCs生物学研究进展及应用潜力,以期为hAMSCs的实验研究和临床应用提供理论依据。Stem cell transplantation has been regarded as an attractive alternative therapy in medical research and clinical trials.It is confirmed by numerous experimental model studies that stem cell transplantation can repair damaged or degraded tissues and restore their function.However,immune rejection,ethical barriers and tumorigenicity are still the difficulties in the practical applications of stem cell therapy.In recent years,perinatal stem cells have been paid increasing attention by researchers as a potential source of cells to solve the above-mentioned problems.Compared with other stem cells,human amniotic stem cells(hAMSCs)show significant advantages in these aspects.Animal experiments have found that hAMSCs have high differentiation potential and immunomodulatory activity,demonstrating great potential for the treatment of gynecological diseases,neurological diseases,kidney diseases,lung diseases,skin diseases,diabetes,cancer and other diseases.At present,with the progress of science and to meet urgent clinical needs,the clinical application of hAMSCs has gradually broken through the limitations of traditional treatment.Many clinical studies have been registered to study the effectiveness and safety of hAMSCs,and some studies have been completed as planned,which has important guiding significance for clinical practice.Therefore,this article reviews the biological research progress and application potential of hAMSCs,in order to provide theoretical basis for experimental research and clinical application of hAMSCs.

关 键 词：人羊膜来源干细胞 人羊膜上皮干细胞 人羊膜间充质干细胞 生物学特性 

分 类 号：Q813[生物学—生物工程]