不同剂量羟考酮对胃肠镜检查疼痛的影响  

Effect of Different Doses of Oxycodone on Pain During Gastroenteroscopy

作　　者：顾美蓉[1] 彭倩[1] GU Mei-rong;PENG Qian(Department of Anesthesiology,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214023,China)

机构地区：[1]南京医科大学附属无锡市人民医院麻醉科,江苏无锡214023

出　　处：《河北北方学院学报（自然科学版）》2023年第4期11-13,18,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨不同剂量羟考酮复合丙泊酚麻醉在无痛胃肠镜检查中的应用效果。方法105例行无痛胃肠镜检查的患者随机分为不同剂量羟考酮复合丙泊酚麻醉组各35例,均使用羟考酮复合丙泊酚麻醉,A组静脉推注羟考酮0.05 mg·kg^(-1)、B组0.08 mg·kg^(-1)、C组0.11 mg·kg^(-1),5 min后各组再推注丙泊酚1.5~2.0 mg·kg^(-1)。观察各组患者丙泊酚用量、胃肠镜检查时间和苏醒时间及患者入室时(T_(0))、诱导后1 min(T_(1))、胃肠镜入镜时(T_(2))、胃肠镜过肝曲时(T_(3))心率(HR)、平均动脉压(MAP)。观察患者低血压、呼吸抑制、注射痛、体动等麻醉不良反应情况。结果A组苏醒时间用时最长,B组用时最短,组间比较差异有统计学意义(P<0.01)。T_(1)-T_(3)时刻3组患者HR、MAP较T_(0)时刻均有不同程度降低(P<0.05);C组患者T_(1)-T_(3)时刻HR明显低于A、B组(P<0.05)。A组患者麻醉不良反应率为34.29%,B组为11.43%,C组为25.71%;A组与B组比较差异有统计学意义(P<0.05)。结论羟考酮复合丙泊酚是无痛胃肠镜检查的可行麻醉方案,应用0.08 mg·kg^(-1)羟考酮具有苏醒时间短、不良反应少及HR、MAP相对稳定的优点,值得参考应用。Objective To explore the application effect of different doses of oxycodone combined with propofol anesthesia in painless gastroenteroscopy.Methods A total of 105 patients who underwent painless gastroenteroscopy were randomly divided into different doses of oxycodone combined with propofol anesthesia groups,with 35 patients in each group receiving oxycodone combined with propofol anesthesia.Group A received intravenous injection of 0.05 mg·kg^(-1)of oxycodone,Group B received 0.08 mg·kg^(-1),and Group C received 0.11 mg·kg^(-1).After 5 minutes,each group received intravenous injection of 1.5~2.0 mg·kg^(-1)of propofol.The dosage of propofol,gastroscopy examination time and awakening time of each group were observed,as well as the heart rate(HR)and mean arterial pressure(MAP)at the time of patient entry(T_(0)),1 minute after induction(T_(1)),gastroscopy entry(T_(2)),and gastroscopy liver curvature(T_(3)).The patient's adverse reactions to anesthesia were observed,such as hypotension,respiratory suppression,injection pain,and physical activity.Results Group A had the longest awakening time,while Group B had the shortest time.There was a statistically significant difference between the two groups(P<0.01).Compared with T_(0)time,HR and MAP of three groups at T_(1)-T_(3)time decreased to different degrees(P<0.05);HR of group C at T_(1)-T_(3)was significantly lower than those of group A and B(P<0.05).The adverse reaction rate of anesthesia in group A patients was 34.29%,11.43%in group B,and 25.71%in group C;The difference between Group A and Group B was statistically significant(P<0.05).Conclusion Oxycodone combined with propofol is a feasible anesthesia scheme for painless gastroenteroscopy.The application of 0.08 mg·kg^(-1)oxycodone has the advantages of short awakening time,fewer adverse reactions,and relatively stable HR and MAP,which is worth reference and application.

关 键 词：无痛胃肠镜 羟考酮 丙泊酚 苏醒时间 不良反应 

分 类 号：R614[医药卫生—麻醉学]