弓形虫病治疗:从传统药物到纳米药物  

Unravelling Toxoplasma Treatment:Conventional Drugs toward Nanomedicine

作　　者：孙晓敬 张磊 田甜 马茜 姚佳 汪洋 SUN Xiaojing;ZHANG Lei;TIAN Tian;MA Xi;YAO Jia;WANG Yang(Department of Pathogen Biology,School of Basic Medical Sciences,Xi’an Medical University,Xi’an 710021,China)

机构地区：[1]西安医学院基础医学部病原生物学教研室,西安710021

出　　处：《畜牧兽医学报》2023年第5期1834-1844,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：陕西省教育厅重点科学研究计划项目(20JS140);陕西省科技厅青年基金项目(2022JQ-216)。

摘　　要：刚地弓形虫(Toxoplasma gondii)是一种呈世界性分布的机会致病原虫,几乎感染所有的温血动物,引起人兽共患弓形虫病。免疫力正常的个体感染常呈隐性感染,无明显的临床症状;但免疫功能缺陷的人或动物感染则会导致严重后果,需进行有效治疗。目前,弓形虫病已是全世界绵羊和山羊流产的常见原因,该病给人类健康和畜牧业生产都造成了严重影响。因此,控制人和动物弓形虫病对公共卫生和畜牧业经济发展极为重要。以往用于弓形虫病治疗的药物,由于其副作用和/或疾病分期的特点,治疗效果大大受限,然而纳米药物可有效克服传统药物的局限性。本文就纳米技术在弓形虫病治疗方面的新进展作一综述,以期为抗弓形虫病药物的研究提供新思路。Toxoplasma gondii is a worldwide obligate intracellular protozoa that infects almost all warm-blooded animals and causes zoonotic toxoplasmosis.Individuals with normal immune function are often infected with Toxoplasma gondii without obvious clinical symptoms and show recessive infection,but pregnant women and individuals with immune deficiency can lead to serious consequences and need effective treatment.Toxoplasmosis is a common cause of abortion in sheep and goats worldwide.And it has a serious impact on human health and livestock production.Therefore,the control of human and animal toxoplasmosis is very important for public health and the economic development of animal husbandry.Previous drugs used to treat toxoplasmosis have been limited in their effectiveness due to side effects and/or disease staging.How-ever,nanoparticles can effectively overcome the limitations of traditional drugs.This article reviews the new progress of nanotechnology in the treatment of toxoplasmosis,in order to provide new ideas for the research of anti-toxoplasmosis drugs.

关 键 词：弓形虫 传统药物 纳米载药系统 固体脂质纳米粒 聚合物纳米粒子 

分 类 号：S853.32[农业科学—临床兽医学]