经辅助生殖技术与高危自然受孕胎儿合并心血管异常特征  

Characteristic of cardiovascular abnormalities between assisted reproductive technology and high-risk natural conception fetuses

作　　者：满婷婷[1,2] 阮燕萍[1,2] 韩建成[1,2] 郝晓艳[1,2] 刘晓伟[1,2] 何怡华[1,2] MAN Tingting;RUAN Yanping;HAN Jiancheng;HAO Xiaoyan;LIU Xiaowei;HE Yihua(Echocardiography Medical Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Maternal-Fetal Medicine Center in Fetal Heart Disease,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心脏超声医学中心,北京100029 [2]首都医科大学附属北京安贞医院胎儿心脏病母胎医学中心,北京100029

出　　处：《中国医学影像技术》2023年第5期705-708,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金项目(82170301、U21A20523);胎儿心脏病母胎医学研究北京市重点实验室(BZ0308)。

摘　　要：目的观察经辅助生殖技术(ART)与高危自然受孕(NC)胎儿所合并心血管异常(CA)的特征。方法回顾性分析6702名接受产前胎儿(6823胎)超声心动图检查的孕妇,其中285名经ART受孕(293胎)(ART组),6417名为NC合并高危因素(6530胎)孕妇(NC组);对比观察2组胎儿合并CA风险、类型及其分级。结果2组孕妇转诊原因、配偶吸烟史及饮酒史差异均有统计学意义(P均<0.05)。ART组(19.11%,56/293)与NC组(16.85%,1100/6530)胎儿CA检出率差异无统计学意义(P>0.05)。2组胎儿CA均以结构性心脏病为主要类型;ART组47胎结构性心脏病中,室间隔缺损9胎,永存左上腔静脉7胎,右位主动脉弓7胎,法洛四联症5胎及肺动脉瓣狭窄4胎;NC组942胎结构性心脏病中,上述病变分别占230胎、104胎、98胎、81胎及52胎;CA病变分级均以Ⅱ级为主,组间CA类型及分级差异均无统计学意义(P均>0.05)。结论经ART受孕胎儿与高危NC胎儿合并CA风险类似,常见类型均为结构性心脏病、尤其室间隔缺损,分级均以Ⅱ级为主。Objective To observe the characteristic of cardiovascular abnormalities(CA)between assisted reproductive technology(ART)and high-risk natural conception(NC)fetuses.Methods Totally 6702 pregnant women who underwent prenatal fetal echocardiography were retrospectively enrolled,including 285 ART pregnant women(293 fetuses)(ART group)and 6417 NC pregnant women with high-risk factors(6530 fetuses)(NC group).The risk,type and grade of fetal CA were observed and compared between 2 groups.Results There were significant differences of referral reasons,spouse smoking history and alcohol consumption history between ART group and NC group(all P<0.05).There was no significant difference of detection rate of fetal CA between ART group(19.11%,56/293)and NC group(16.85%,1100/6530)(P>0.05).There was no significant difference of type nor grade of fetal CA between 2 groups(both P>0.05),and the main types of CA were both structural heart disease in 2 groups,including 47 cases(9 cases of ventricular septal defect,7 cases of persistent left superior vena cava,7 cases of right aortic arch,5 cases of tetralogy of Fallot and 4 cases of pulmonary valve stenosis)in ART group and 942 cases(230,104,98,81 and 52 cases)in NC group,and were both mainly of gradeⅡ.Conclusion The risk of CA of ART fetus was similar to that of high-risk NC fetus,and the mainly grade of CA were both gradeⅡ,the common types were both structural heart disease,especially ventricular septal defect.

关 键 词：胎儿 心血管畸形 生殖技术 辅助 超声心动描记术 

分 类 号：R714.53[医药卫生—妇产科学] R540.45[医药卫生—临床医学]