左卡尼汀联合促红细胞生成素对维持性血液透析肾性贫血患者的疗效观察  

Clinical effect of L-carnitine combined with erythropoietin on renal anemia patients with maintenance hemodialysis

作　　者：孙姝 孙佳丽 孙永辉 王菁[1] Sun Shu;Sun Jiali;Sun Yonghui;Wang Jing(Department of Nephrology,Haiyang People's Hospital,Haiyang 265100,China)

机构地区：[1]海阳市人民医院肾内科,海阳265100

出　　处：《中国实用医刊》2023年第4期94-96,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨左卡尼汀联合促红细胞生成素治疗维持性血液透析肾性贫血患者的临床效果。方法抽取2019年6月至2021年6月海阳市人民医院收治的肾性贫血且采用维持性血液透析治疗的300例患者作为研究对象,按照随机双盲原则将其分为联合组和对照组,每组150例。对照组采用促红细胞生成素治疗,联合组在对照组基础上联合应用左卡尼汀治疗,比较两组的临床疗效及贫血指标、红细胞携氧能力及不良反应发生情况。结果联合组的总有效率(97.33%,146/150)高于对照组(80.67%,121/150),差异有统计学意义(P<0.05);治疗前,两组患者血红蛋白(Hb)、血细胞比容(HCT)及血清铁蛋白(SF)水平比较差异未见统计学意义(P>0.05);治疗后,两组患者各指标水平均明显升高,且联合组的升高幅度明显优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者红细胞有效携氧量(Q值)和氧亲和力(P50)比较差异未见统计学意义(P>0.05),治疗后,两组患者Q值和P50均明显改善,且联合组的改善效果明显优于对照组,差异有统计学意义(P<0.05)。联合组和对照组患者治疗期间不良反应发生率比较差异未见统计学意义(P>0.05)。结论左卡尼汀联合促红细胞生成素用于维持性血液透析肾性贫血患者的治疗,效果较好,患者贫血状态明显改善,且安全高效。Objective To investigate the clinical efficacy of L-carnitine combined with erythropoietin on renal anemia patients with maintenance hemodialysis.Methods A total of 300 patients with renal anemia who were treated by maintenance hemodialysis in Haiyang People’s Hospital from June 2019 to June 2021 were selected,and they were divided into combined group and control group by double-blind method,with 150 cases in each group.The control group was treated with erythropoietin,while the combined group was treated with L-carnitine based on the treatment of the control group.The clinical efficacy,anemia indexes,oxygen carrying capacity of red blood cells and the incidence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group(97.33%,146/150)was significantly higher than that of the control group(80.67%,121/150),and the difference was significant(P<0.05);before treatment,there was no significant difference in the levels of hemoglobin(Hb),hematocrit(HCT)and serum ferritin(SF)between the two groups(P>0.05);after treatment,the levels of these indexes of the two groups were significantly increased,and the increase of the combined group was superior to that of the control group,and the difference was significant(P<0.05).Before treatment,there was no significant difference in the effective oxygen carrying capacity(Q value)and oxygen affinity(P50)of red blood cells between the two groups(P>0.05).After treatment,the Q value and P50 of the two groups were improved,and the improvement of the combined group was significantly better than that of the control group,and the difference was significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and the control group(P>0.05).Conclusions L-carnitine combined with erythropoietin has good effects in the treatment of renal anemia patients with maintenance hemodialysis,which can significantly improve anemia status,with good safety.

关 键 词：血液透析 肾性贫血 左卡尼汀 促红细胞生成素 临床疗效 

分 类 号：R692.5[医药卫生—泌尿科学]