黄体酮治疗闭经、无排卵性功能失调性子宫出血的效果  

Effect of Progesterone on Amenorrhea and Anovulatory Dysfunctional Uterine Bleeding

作　　者：卞荣芳 BIAN Rongfang(Department of Obstetrics and Gynecology,Yancheng No.1 People's Hospital Affiliated Hospital of Medical School Nanjing University,Yancheng,Jiangsu Province,224002 China)

机构地区：[1]南京医科大学附属盐城第一人民医院妇产科,江苏盐城224002

出　　处：《中外医疗》2023年第2期107-110,共4页China & Foreign Medical Treatment

摘　　要：目的对闭经及无排卵性功能失调性子宫出血患者应用黄体酮胶囊、地屈孕酮治疗的临床效果进行分析。方法方便选择2020年1月—2021年10月南京医科大学附属盐城第一人民医院收治的64例闭经及无排卵性功能失调性子宫出血患者为研究对象,按照治疗方式的不同将其分为研究组(n=32)与对照组(n=32)。对照组用黄体酮胶囊,研究组在对照组基础上加用地屈孕酮,比较两组临床疗效、不良反应、月经周期和经期出血量和阴道出血持续时间。结果研究组第1周出血量正常占比(84.38%)高于对照组(59.38%),第2周出血量正常占比(93.75%)高于对照组(65.63%),第3周出血量正常占比(96.88%)高于对照组(68.75%),差异有统计学意义(P<0.05)。研究组第1周阴道出血持续时间为(4.3±1.1)d,第2周为(4.1±0.7)d,第3周为(3.7±0.3)d,明显短于对照组,差异有统计学意义(P<0.05)。研究组月经周期(26.21±2.29)d、经期(5.83±1.95)d短于对照组,差异有统计学意义(P<0.05)。研究组显效18例、有效11例、无效3例,总有效率为90.63%,对照组显效10例,有效12例,无效10例,总有效率为68.75%,两组总有效率比较,差异有统计学意义(χ^(2)=4.730,P=0.030)。研究组有1例头昏,1例呕吐,对照组有3例头昏,2例恶心,2例头痛,2例呕吐,研究组不良反应发生率(6.25%)明显低于对照组(28.13%),差异有统计学意义(χ^(2)=5.379,P=0.020)。结论黄体酮联合地屈孕酮治疗闭经及无排卵性功能失调性子宫出血效果显著,可减少出血量,缩短月经周期,安全性高。Objective To analyze the clinical effects of progesterone capsules and dydrogesterone in patients with amenorrhea or anovulatory dysfunctional uterine bleeding.Methods Sixty-four patients with amenorrhea and anovula⁃tory dysfunctional uterine bleeding admitted to Yancheng No.1 People's Hospital Affiliated Hospital of Medical School Nanjing University from January 2020 to October 2021 were convenient selected as the research objects.According to different treatment methods,they were divided into study group(n=32)and control group(n=32).The control group was treated with progesterone capsules,and the study group was treated with drogesterone on the basis of the control group.The clinical efficacy,adverse reactions,menstrual cycle and menstrual bleeding and the duration of vaginal bleeding were compared between the two groups.Results The proportion of normal blood loss in the study group in the first week(84.38%)was higher than that in the control group(59.38%),the proportion of normal blood loss in the sec⁃ond week(93.75%)was higher than that in the control group(65.63%),and the proportion of normal blood loss in the third week(96.88%)was higher than that in the control group(68.75%),the difference was statistically significant(P<0.05).The duration of vaginal bleeding in the study group was(4.3±1.1)d in the first week,(4.1±0.7)d in the second week and(3.7±0.3)d in the third week,which were significantly shorter than those in the control group,and the differ⁃ence was statistically significant(P<0.05).The menstrual cycle(26.21±2.29)d and menstrual period(5.83±1.95)d in the study group were shorter than those in the control group,and the difference was statistically significant(P<0.05).In the study group,18 cases were markedly effective,effective in 11 cases,3 cases ineffective,the total effective rate was 90.63%;in the control group,10 cases were markedly effective,effective 12 cases,10 cases were ineffective,the total effective rate was 68.75%,two groups total effective rate comparison,the difference was

关 键 词：子宫出血 功能失调 黄体酮 无排卵 疗效研究 

分 类 号：R4[医药卫生—临床医学]