Klotho蛋白与Wnt信号通路在骨代谢中的研究进展  

Research Advances in Klotho Protein and Wnt Signaling Pathway in Bone Metabolism

作　　者：王森 马厚勋[1] 李宝善 Wang Sen;Ma Houxun;Li Baoshan(Department of Geriatrics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 40016;Department of Geriatrics,Chongqing University Central Hospital/Chongqing Emergency Medical Center,Chongqing 40016)

机构地区：[1]重庆医科大学附属第一医院老年病科,重庆400016 [2]重庆大学附属中心医院重庆市急救医疗中心老年病科,重庆400016

出　　处：《国际老年医学杂志》2023年第3期351-353,共3页International Journal of Geriatrics

基　　金：重庆市2020年科卫联合医学科研项目(2020FYYX134)。

摘　　要：Klotho蛋白可通过调节磷酸盐、骨矿化、维生素D及成骨细胞和破骨细胞的分化成熟、生物活性与细胞凋亡等机制影响骨代谢过程。而Wnt信号通路在成骨细胞分化成熟、骨骼发育和骨量维持中起关键作用。Klotho蛋白可能通过Wnt信号通路参与骨代谢过程。本文对Klotho蛋白与Wnt信号通路在骨代谢中的相互作用及其机制作一综述,为骨质疏松症的早期干预与治疗提供新的思路。Klotho protein can affect the process of bone metabolism by regulating the homeostasis of the hormones such as phosphate,bone mineralization and vitamin D,and acting on osteoblasts,osteoclast differentiation and maturation,biological activity and apoptosis.Wnt signaling pathway plays a key role in osteoblast maturation and differentiation,bone development and bone mass maintenance.Klotho protein may participate in bone metabolism through the Wnt signaling pathway.This paper reviews the interaction between Klotho protein and Wnt signaling pathway in bone metabolism and its mechanism,so as to provide new clues for the early prevention and intervention of osteoporosis.

关 键 词：KLOTHO蛋白 WNT信号通路 骨代谢 骨质疏松症 

分 类 号：R68[医药卫生—骨科学]