肺部及中枢神经系统尖端赛多孢子菌感染1例并文献复习  

Pulmonary infection and encephalopyosis induced by Scedosporium apiospermum:a case report and literatures review

作　　者：曹雅[1] 谭清澈 张家堂[1] 赵红[1] 苏敏 马玉宝[1] 何绵旺[1] 杨飞[1] 于生元[1] CAO Ya;TAN Qingche;ZHANG Jiatang;ZHAO Hong;SU Min;MA Yubao;HE Mianwang;YANG Fei;YU Shengyuan(Department of Neurology,The First Medical Centre,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心神经内科医学部,北京100853

出　　处：《中国真菌学杂志》2023年第2期146-150,共5页Chinese Journal of Mycology

摘　　要：报道我院收治尖端赛多孢子菌致肺部及中枢神经系统感染1例,并探讨其治疗措施。取患者肺泡灌洗液、脑脊液、颅内引流物进行病原学培养及宏基因组二代基因检测,根据菌株的形态学特点和基因测序结果鉴定为尖端赛多孢子菌。手术引流及伏立康唑抗真菌治疗效果明显,但仍需进一步随访。To reported one case of pulmonary infection and encephalopyosis caused by Scedosporium apiospermum,and to discuss the clinical features and the treatment.The patient’s broncholveolr lvge fluid,cerebrospinal fluid and intracranial drainage specimens were taken for fungal culture and morphological identification,and next generation sequencing.Surgical drainage and voriconazole antifungal therapy were used.According to the morphological characteristics of the strain and the results of gene sequencing,it was identified as Scedosporium apiospermum.Pulmonary and central nervous system fungal infections caused by Scedosporium apiospermum are less common and their identification relies primarily on morphological features and genetic analysis.Surgical drainage and voriconazole have a good therapeutic effect on this.However,a further follow-up is requied.

关 键 词：尖端赛多孢子菌 肺部感染 中枢神经系统感染 脑脓肿 治疗措施 

分 类 号：R519.8[医药卫生—内科学]