马尔尼菲篮状菌致HIV阴性患者眼睑脓肿1例  

A case of eyelid abscess caused by Talaromyces marneffei in non-HIV patient

作　　者：胡琴 吴琼[2] 欧阳奕[3] HU Qin;WU Qiong;OUYANG Yi(Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Laboratory Medicine,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Infectious Diseases,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院药学部,长沙410008 [2]中南大学湘雅医院检验科,长沙410008 [3]中南大学湘雅医院感染病科,长沙410008

出　　处：《中国真菌学杂志》2023年第2期156-159,共4页Chinese Journal of Mycology

基　　金：湖南省自然科学基金项目(2022JJ80045)。

摘　　要：患者,女,43岁,发现颈部多发淋巴结肿大11个月,取淋巴结活检后诊断为“淋巴结核”,抗结核治疗期间患者左上眼睑出现肿胀,行“左眼眼眶肿物摘除术(前路开眶)+带蒂皮瓣移植术”,术后脓液培养示:马尔尼菲篮状菌,初始予两性霉素B治疗,后因肌酐升高改为口服伊曲康唑200 mg, 2次/天,治疗7周后好转出院。院外口服伊曲康唑200 mg, 2次/天,6个月后续以200 mg, 1次/天,治疗8个月,随访两年未复发。A 43-year-old woman was found to have multiple swollen lymph nodes in the neck with a 11-month history.After taking a lymph node biopsy,she was diagnosed as"lymphatic tuberculosis."During anti-tuberculosis treatment,the patient experienced swelling of the upper left eyelid.She received“mass removal(anterior opening of the orbit)+pedicle flap transplantation”,postoperative pus culture showed:Talaromyces marneffei.Treatment with intravenous amphotericin B was initiated,and later changed to itraconazole 200 mg twice-daily orally due to increased creatinine.The patient was discharged after totally 7 weeks treatment.Oral itraconazole 200 mg twice-daily was continued for 6 months followed by 200mg qd for 8 months,and there was no recurrence during a two-year follow-up.

关 键 词：马尔尼菲篮状菌 HIV阴性 两性霉素B 伊曲康唑 眼睑脓肿 

分 类 号：R519.8[医药卫生—内科学]