雷帕霉素在银屑病治疗中的研究进展  

Research progress of rapamycin in treatment of psoriasis

作　　者：林雅雯 付芳惠 马蕾(指导)[1] LIN Yawen;FU Fanghui;MA Lei(Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院,滨州256603

出　　处：《中国免疫学杂志》2023年第5期1085-1088,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81803145)资助。

摘　　要：银屑病是一种免疫介导的炎症性皮肤病,已有研究表明PI3K/AKT/mTORC1信号通路在银屑病疾病过程中发挥重要作用。雷帕霉素作为mTORC1抑制剂,可以通过改善银屑病患者角质形成细胞异常功能状态、血管异常增生以及调节Th17细胞免疫功能等机制在银屑病治疗中发挥一定的作用。Psoriasis is an immune-mediated inflammatory skin disease.Studies have shown that PI3K/AKT/mTORC1 signaling pathway plays a key role in the pathogenesis of psoriasis.Rapamycin is the inhibitor of mTORC1,which can play a certain role in the treatment of psoriasis by improving the abnormal functional status of keratinocytes and vascular proliferation as well as regulating the immune function Th17 cells in patients with psoriasis.

关 键 词：雷帕霉素 银屑病 PI3K/AKT/mTORC1信号通路 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]