细胞力学2022年度研究进展  

Progress of Cell Mechanics in 2022

作　　者：杨月华 公泽 杨皓翔 姜洪源[1] YANG Yuehua;GONG Ze;YANG Haoxiang;JIANG Hongyuan(Department of Modern Mechanics,School of Engineering and Science,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学技术大学工程科学学院,近代力学系,合肥230026

出　　处：《医用生物力学》2023年第2期212-219,共8页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12002338,12202439,12025207,11872357)。

摘　　要：细胞的力学微环境在调控其生理功能方面起关键作用。体内细胞经常受到剪切、拉伸、压缩等多种力学载荷,并且可以通过黏附分子(如整合素-配体素的结合)连接到细胞外基质上,进而可以感知外基质的硬度。细胞力学主要研究活细胞在力学载荷下的力学特性和行为,以及这些特征和行为与细胞功能的关系。本文综述2022年度细胞力学领域的研究进展,主要关注整合素-配体素间的相互作用,以及外基质硬度和力学载荷对细胞生理行为和形态发生的影响。The mechanical microenvironment of cells plays a critical role in regulating the physiological function of cells.Cells in vivo are often subjected to a variety of mechanical forces from their mechanical micro-environment,such as shear,tension,and compression.At the same time,cells can adhere to the extracellular matrix(ECM)through adhesion molecules(such as integrin-ligand binding),and further sense the stiffness of the ECM.Cell mechanics mainly studies the properties and behaviors of living cells under mechanical forces,and how they relate to cell functions.This review summarized the advances in cell mechanics in 2022,focusing on integrinligand interactions and the effects of matrix stiffness and mechanical forces on cell physiological behavior and morphogenesis.

关 键 词：细胞力学 力学微环境 基质硬度 力学载荷 

分 类 号：R318.01[医药卫生—生物医学工程]